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  • Hybrids and plug-ins
  • MY2010

Most Fuel-Efficient Hybrids of 2010

The most efficient 2010 hybrid is the Toyota Prius (1.8 L · FWD) at 50 MPG combined, 21 MPG above the median hybrid (29 MPG) among the 25 hybrids ranked. The Toyota Prius costs about $1,310 a year to fuel, $1,020 less than the median hybrid ($2,330).

The top 10 run from 50 MPG to 32 MPG. Each model is listed once, with its best qualifying configuration named in the row; models with the same displayed value share a rank.

Best combined

50MPG

Toyota Prius

Median model

29MPG

25 models

Top-10 median

37MPG

Models ranked

25

one row per model

Full ranking

All 25 models. Every column is sortable.

Most Fuel-Efficient Hybrids of 2010: top 25 of 25 models
1
Toyota Prius
1.8 L · FWD
Midsize cars · Hybrid
505148$1,310+21
2
Honda Civic
Hybrid · 1.3 L · FWD
Small cars · Hybrid
424045$1,560+13
3
Honda Insight
1.3 L · FWD
Small cars · Hybrid
414043$1,590+12
4
Ford Fusion
Hybrid · 2.5 L · FWD
Midsize cars · Hybrid
394136$1,680+10
4
Mercury Milan
Hybrid · 2.5 L · FWD
Midsize cars · Hybrid
394136$1,680+10
6
Lexus HS
250h · 2.4 L · FWD
Small cars · Hybrid
353534$1,870+6
7
Nissan Altima
Hybrid · 2.5 L · FWD
Midsize cars · Hybrid
343533$1,920+5
7
Toyota Camry
Hybrid · 2.4 L · FWD
Midsize cars · Hybrid
343334$1,920+5
9
Ford Escape
Hybrid · 2.5 L · FWD
Standard SUVs · Hybrid
323431$2,040+3
9
Mazda Tribute
Hybrid · 2.5 L · FWD
Standard SUVs · Hybrid
323431$2,040+3
9
Mercury Mariner
Hybrid · 2.5 L · FWD
Standard SUVs · Hybrid
323431$2,040+3
12
Lexus RX
450h · 3.5 L · FWD
Standard SUVs · Hybrid · Premium fuel
303228$2,680+1
13
Chevrolet Malibu
Hybrid · 2.4 L · FWD
Midsize cars · Hybrid
292634$2,2500
14
Saturn Vue
Hybrid · 2.4 L · FWD
Standard SUVs · Hybrid
282532$2,330−1
15
Toyota Highlander
Hybrid · 3.3 L · AWD
Standard SUVs · Hybrid
262725$2,510−3
16
Lexus GS
450h · 3.5 L · RWD
Midsize cars · Hybrid · Premium fuel
232225$3,490−6
17
Cadillac Escalade
Hybrid · 6.0 L · RWD
Standard SUVs · Hybrid
222122$2,970−7
17
Chevrolet Silverado
15 Hybrid · 6.0 L · RWD
Standard pickups · Hybrid
222122$2,970−7
17
Chevrolet Tahoe
Hybrid · 6.0 L · RWD
Standard SUVs · Hybrid
222122$2,970−7
17
GMC Sierra
15 Hybrid · 6.0 L · RWD
Standard pickups · Hybrid
222122$2,970−7
17
GMC Yukon
1500 Hybrid · 6.0 L · RWD
Standard SUVs · Hybrid
222122$2,970−7
17
Mercedes-Benz ML-Class
ML450 Hybrid 4matic · 3.5 L · 4WD
Standard SUVs · Hybrid · Premium fuel
222124$3,650−7
23
Lexus LS
600h L · 5.0 L · AWD
Midsize cars · Hybrid · Premium fuel
212022$3,830−8
23
Mercedes-Benz S-Class
S400 Hybrid · 3.5 L · RWD
Large cars · Hybrid · Premium fuel
211925$3,830−8
25
BMW ActiveHybrid X6
4.4 L · AWD
Standard SUVs · Hybrid · Premium fuel
181719$4,460−11

How this list is built

Every line below is read from the list definition that produced the table.

  • Classes: every EPA class except special-purpose vehicles.
  • Powertrains: Hybrid.
  • Ranked by EPA combined MPG, highest first.
  • One row per model (make and model): the configuration that ranks best in this list is shown, with its trim, engine and drive named in the row.
  • Ties are decided on the displayed value (whole MPG or miles, kWh per 100 miles to one decimal, cost rounded to $10): tied models share a rank, then are ordered by a tie-breaker and by name.
  • Special-purpose vehicles, such as heavy-duty variants, are excluded.
  • Electric vehicles are ranked separately (see the EV rankings): gas, hybrid and diesel MPG is never mixed with MPGe.
  • Annual cost assumes 15,000 miles a year at the EPA rating and the dated national fuel prices stamped below; it is rounded to $10 and all differences use the rounded values.
  • Model years MY2006 to MY2027; a year is listed only when at least 10 models qualify.

Data and period

  • EPA ratings: fueleconomy.gov file of Sep 29, 2026
  • Prices: EIA regular gasoline, U.S. average, Sep 2026 ($4.36/gal); residential electricity, U.S. average, Jul 2026 (18.3¢/kWh)
  • 15,000 miles a year, 55% city and 45% highway

Frequently asked questions

Which 2010 hybrid gets the best gas mileage?

The most efficient 2010 hybrid is the Toyota Prius (1.8 L · FWD) at 50 MPG combined, 21 MPG above the median hybrid (29 MPG) among the 25 hybrids ranked. The Toyota Prius costs about $1,310 a year to fuel, $1,020 less than the median hybrid ($2,330).

How much does the Toyota Prius cost to fuel per year?

About $1,310 a year at 15,000 miles a year, using the prices stamped at the bottom of this page. The median hybrid in this list costs $2,330 a year.

How many hybrids are ranked for 2010?

25 models qualify, one row each. The median is 29 MPG, and the top 10 run from 50 MPG to 32 MPG.

How are ties, trims and drivetrains handled?

Each model appears once, with the configuration that ranks best in this list; its trim, engine and drive are named in the row. Models with the same displayed value share a rank (1, 2, 2, 4) and are then ordered by a tie-breaker and by name. See the methodology.

Are electric cars and plug-in hybrids included?

Not in this list. MPG rankings cover gas, hybrid and diesel models only. Electric cars are ranked in EV range and EV efficiency, and plug-in hybrids in electric range.

What does combined MPG mean?

EPA's combined rating blends 55% city and 45% highway driving. It comes from standardized laboratory tests, so your results will differ with driving style, weather and load. See the methodology.

EPA ratings: fueleconomy.gov file of Sep 29, 2026 · Prices: EIA regular gasoline, U.S. average, Sep 2026 ($4.36/gal); residential electricity, U.S. average, Jul 2026 (18.3¢/kWh) · 15,000 miles a year, 55% city and 45% highway