2007-2012 Nissan Altima MPG & Fuel Cost

EPA rates the 2007-2012 Nissan Altima at 21–34 MPG combined across 44 configurations and 6 model years. The most efficient version, the 2010 Hybrid 2.5L 4-cyl FWD, is rated 34 MPG (35 city, 33 highway). By powertrain: Gas: 21–27 MPG; Hybrid: 33–34 MPG.

The Hybrid 2.5L 4-cyl FWD reached the generation's best combined rating, 34 MPG, in 2007, 2008, 2009 and 2010. The lowest top rating, 26 MPG, was in 2012.

Yes. Ratings changed in 2008, 2009, 2010, 2011 and 2012.

The previous generation (2002-2006 Nissan Altima) is rated 19–24 MPG combined and costs $2,720–$3,440 a year to fuel; the 2007-2012 model is rated 21–34 MPG and costs $1,920–$3,830 a year.

Driving 15,000 miles a year at regular gasoline $4.36/gal (U.S. average, Sep 2026), the Altima 2.5L 4-cyl FWD costs about $2,480 a year. Across all 6 configurations the cost runs $2,480–$3,060 a year. That is a $580 difference between the cheapest and the costliest configuration.

About $16.53 per 100 miles for the Altima 2.5L 4-cyl FWD at regular gasoline $4.36/gal (U.S. average, Sep 2026), and between $16.53 and $20.40 across all configurations. That is the annual cost over 15,000 miles divided by 150.

The Altima 2.5L 4-cyl FWD is rated 23 city and 32 highway MPG, so it is more efficient on the highway, by 9 MPG.

The Altima 2.5L 4-cyl FWD costs about $2,480 a year to fuel, $760 less than the class median of $3,240, and less than 8 of 10 small car configurations. The comparison covers all 375 rated small car configurations for MY2012, not weighted by sales.

The most efficient configuration moves from 33 to 26 MPG, down 7. Its annual cost goes from $1,970 to $2,480, $510 more. EPA lists 6 configurations for 2012 against 7 configurations for 2011. See the 2011 Nissan Altima for that year.