2010-2015 Lexus RX MPG & Fuel Cost

EPA rates the 2010-2015 Lexus RX at 20–30 MPG combined across 27 configurations and 6 model years. The most efficient version, the 2010 450h 3.5L 6-cyl FWD, is rated 30 MPG (32 city, 28 highway). By powertrain: Gas: 20–21 MPG; Hybrid: 28–30 MPG.

The 450h 3.5L 6-cyl FWD reached the generation's best combined rating, 30 MPG, in 2010. The lowest top rating, 29 MPG, was in 2011, 2012, 2013, 2014 and 2015.

Yes. Ratings changed in 2011, 2012, 2013, 2014 and 2015.

The previous generation (2004-2009 Lexus RX) is rated 18–27 MPG combined and costs $2,420–$4,460 a year to fuel; the 2010-2015 model is rated 20–30 MPG and costs $2,680–$4,020 a year.

Driving 15,000 miles a year at regular gasoline $4.36/gal (U.S. average, Sep 2026), the 350 3.5L 6-cyl AWD costs about $3,090 a year. Across all 5 configurations the cost runs $2,730–$3,270 a year. That is a $540 difference between the cheapest and the costliest configuration.

About $20.60 per 100 miles for the 350 3.5L 6-cyl AWD at regular gasoline $4.36/gal (U.S. average, Sep 2026), and between $18.20 and $21.80 across all configurations. That is the annual cost over 15,000 miles divided by 150.

The 350 3.5L 6-cyl AWD costs about $3,090 a year to fuel, $100 more than the class median of $2,990, and less than 4 of 10 small SUV configurations. The comparison covers all 188 rated small SUV configurations for MY2015, not weighted by sales.

Yes. The best hybrid (450h 3.5L 6-cyl FWD) is rated 29 MPG against 21 MPG for the best gas version (350 3.5L 6-cyl AWD), 8 MPG more. At regular gasoline $4.36/gal (U.S. average, Sep 2026) that is $2,730 versus $3,090 a year, a saving of $360.

The most efficient configuration stays at 29 MPG. Its annual cost stays at $2,730. EPA lists 5 configurations for 2015 against 5 configurations for 2014. See the 2014 Lexus RX for that year.