2016-2022 Lexus RX MPG & Fuel Cost

EPA rates the 2016-2022 Lexus RX at 21–30 MPG combined across 37 configurations and 7 model years. The most efficient version, the 2022 450h 3.5L 6-cyl AWD, is rated 30 MPG (31 city, 28 highway). By powertrain: Gas: 21–23 MPG; Hybrid: 29–30 MPG.

Every model year of the 2016-2022 Lexus RX tops out at 30 MPG combined, so no year is better than another.

Yes. Ratings changed in 2017, 2018, 2019, 2020, 2021 and 2022.

The previous generation (2010-2015 Lexus RX) is rated 20–30 MPG combined and costs $2,680–$4,020 a year to fuel; the 2016-2022 model is rated 21–30 MPG and costs $2,650–$3,080 a year.

Driving 15,000 miles a year at regular gasoline $4.36/gal (U.S. average, Sep 2026), the 350 3.5L 6-cyl FWD costs about $2,890 a year. Across all 6 configurations the cost runs $2,700–$3,070 a year. That is a $370 difference between the cheapest and the costliest configuration.

About $19.27 per 100 miles for the 350 3.5L 6-cyl FWD at regular gasoline $4.36/gal (U.S. average, Sep 2026), and between $18.00 and $20.47 across all configurations. That is the annual cost over 15,000 miles divided by 150.

The 350 3.5L 6-cyl FWD costs about $2,890 a year to fuel, $160 more than the class median of $2,730, and less than 4 of 10 small SUV configurations. The comparison covers all 287 rated small SUV configurations for MY2022, not weighted by sales.

Yes. The best hybrid (450h 3.5L 6-cyl AWD) is rated 30 MPG against 23 MPG for the best gas version (350 3.5L 6-cyl FWD), 7 MPG more. At regular gasoline $4.36/gal (U.S. average, Sep 2026) that is $2,700 versus $2,890 a year, a saving of $190.

The most efficient configuration stays at 30 MPG. Its annual cost stays at $2,700. EPA lists 6 configurations for 2022 against 6 configurations for 2021. See the 2021 Lexus RX for that year.