2007-2017 Lexus LS MPG & Fuel Cost

EPA rates the 2007-2017 Lexus LS at 18–21 MPG combined across 49 configurations and 11 model years. The most efficient version, the 2010 600h L 5.0L 8-cyl AWD, is rated 21 MPG (20 city, 22 highway). By powertrain: Gas: 18–20 MPG; Hybrid: 20–21 MPG.

The 600h L 5.0L 8-cyl AWD reached the generation's best combined rating, 21 MPG, in 2008, 2009 and 2010. The lowest top rating, 19 MPG, was in 2017.

Yes. Ratings changed in 2008, 2009, 2010, 2011, 2012, 2013, 2014, 2015, 2016 and 2017.

The previous generation (2001-2006 Lexus LS) is rated 18–19 MPG combined and costs $4,230–$4,460 a year to fuel; the 2007-2017 model is rated 18–21 MPG and costs $3,830–$4,460 a year.

Driving 15,000 miles a year at premium gasoline $5.36/gal (U.S. average, Sep 2026), the 460 4.6L 8-cyl RWD costs about $4,200 a year. Across all 4 configurations the cost runs $4,200–$4,400 a year. That is a $200 difference between the cheapest and the costliest configuration.

About $28.00 per 100 miles for the 460 4.6L 8-cyl RWD at premium gasoline $5.36/gal (U.S. average, Sep 2026), and between $28.00 and $29.33 across all configurations. That is the annual cost over 15,000 miles divided by 150.

The 460 4.6L 8-cyl RWD is rated 16 city and 24 highway MPG, so it is more efficient on the highway, by 8 MPG.

The 460 4.6L 8-cyl RWD costs about $4,200 a year to fuel, $1,290 more than the class median of $2,910, and less than 1 of 10 midsize car configurations. The comparison covers all 180 rated midsize car configurations for MY2017, not weighted by sales.

The most efficient configuration moves from 20 to 19 MPG, down 1. Its annual cost goes from $3,930 to $4,200, $270 more. EPA lists 4 configurations for 2017 against 5 configurations for 2016. See the 2016 Lexus LS for that year.