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2021 Mercedes-Benz S-Class S350d Exclusive
Photo shows the 2021 model (previous generation): 2021 Mercedes-Benz S-Class S350d Exclusive. Photo: Chanokchon, CC BY-SA 4.0, via Wikimedia Commons
  • Newest year: 2027
  • Gas
  • Hybrid
  • Large cars
  • Partial model year

2024-2027 Mercedes-Benz S-Class MPG & Fuel Cost

4 model years · 14–24 MPG combined

23 MPG
Combined
20 MPG
City
28 MPG
Highway
Annual fuel cost · S500 4matic 3.0L 6-cyl turbo supercharged AWD
$3,530

15,000 mi/yr · premium gasoline $5.36/gal (U.S. average, Sep 2026)

Cheaper to fuel than 2 of 10 large car configurations, MY2027. Ranked against all rated configurations, not sales-weighted.

2024-2027 Mercedes-Benz S-Class at a glance

The 2024-2027 Mercedes-Benz S-Class covers 4 model years in the EPA database (18 configurations in all), rated 14–24 MPG combined. The newest model year, 2027, costs about $3,530 a year to fuel for its most efficient version, the S500 4matic 3.0L 6-cyl turbo supercharged AWD (23 MPG), at premium gasoline $5.36/gal (U.S. average, Sep 2026). Powertrains over the years: gas, hybrid and plug-in hybrid. EPA changed the ratings in 2025, 2026 and 2027. The best combined rating in the generation, 24 MPG, was reached in 2024 and 2025.

Model year 2027 is still being filled in by EPA (4 configurations listed so far), so rows may be added.

2024-2027 Mercedes-Benz S-Class by model year

2024-2027 Mercedes-Benz S-Class: EPA combined rating and yearly fuel cost for each model year
Model yearPowertrainsCombined$/yrEPA ratings
2027 (partial) Gas, Hybrid 14–23 MPG $3,530–$5,580 Ratings changed
2026 Gas, Hybrid 15–23 MPG $3,450–$5,500 Ratings changed
2025 Gas, Hybrid, Plug-in hybrid 15–24 MPG $2,000–$5,500 Ratings changed
2024 Gas, Hybrid 15–24 MPG $3,290–$5,500 First year

What the 2027 S500 4matic 3.0L 6-cyl turbo supercharged AWD costs to drive

Per month

$294

$3,530 a year ÷ 12

Per 25 miles

$5.88

Per 100 miles

$23.53

Five years

$17,650

5 × the yearly cost, prices held at today's level

vs the large car median

$2,270more a year

Class median $1,260 a year, MY2027

Based on 15,000 miles a year and premium gasoline $5.36/gal (U.S. average, Sep 2026).

2027 Mercedes-Benz S-Class MPG

Model year 2027 is still being filled in by EPA (4 configurations listed so far), so rows may be added.

Versus 2026: The most efficient configuration stays at 23 MPG. Its annual cost goes from $3,450 to $3,530, $80 more.

Gas · 6.0L
Combined
14 MPG
Per year
$5,580
See gas configurations
Hybrid · 3.0L, 4.0L
Combined
18–23 MPG
Per year
$3,530–$4,410
See hybrid configurations

Gas configurations (1)

2027 Mercedes-Benz S-Class gas configurations: EPA ratings and annual cost
TrimEngineDriveCityHwyComb.$/yr
Maybach S680 4matic (Most efficient) 6.0L 12-cyl turbo AWD 12 20 14 $5,580

1 configuration requires or recommends higher-octane gasoline and is costed at premium gasoline $5.36/gal (U.S. average, Sep 2026).

Hybrid configurations (3)

2027 Mercedes-Benz S-Class hybrid configurations: EPA ratings and annual cost
TrimEngineDriveCityHwyComb.$/yr
S500 4matic (Most efficient) 3.0L 6-cyl turbo supercharged AWD 20 28 23 $3,530
S580 4matic 4.0L 8-cyl turbo AWD 16 24 19 $4,250
S580 4matic Maybach 4.0L 8-cyl turbo AWD 15 24 18 $4,410

3 configurations require or recommend higher-octane gasoline and are costed at premium gasoline $5.36/gal (U.S. average, Sep 2026).

2026 Mercedes-Benz S-Class MPG

15–23 MPG · $3,450–$5,500/yr

Versus 2025: The most efficient configuration moves from 24 to 23 MPG, down 1. Its annual cost goes from $3,290 to $3,450, $160 more.

Gas · 6.0L
Combined
15 MPG
Per year
$5,500
See gas configurations
Hybrid · 3.0L, 4.0L
Combined
20–23 MPG
Per year
$3,450–$4,110
See hybrid configurations

Gas configurations (1)

2026 Mercedes-Benz S-Class gas configurations: EPA ratings and annual cost
TrimEngineDriveCityHwyComb.$/yr
Maybach S680 4matic (Most efficient) 6.0L 12-cyl turbo AWD 12 20 15 $5,500

1 configuration requires or recommends higher-octane gasoline and is costed at premium gasoline $5.36/gal (U.S. average, Sep 2026).

Hybrid configurations (3)

2026 Mercedes-Benz S-Class hybrid configurations: EPA ratings and annual cost
TrimEngineDriveCityHwyComb.$/yr
S500 4matic (Most efficient) 3.0L 6-cyl turbo supercharged AWD 20 29 23 $3,450
S580 4matic 4.0L 8-cyl turbo AWD 17 27 20 $3,970
S580 4matic Maybach 4.0L 8-cyl turbo AWD 16 27 20 $4,110

3 configurations require or recommend higher-octane gasoline and are costed at premium gasoline $5.36/gal (U.S. average, Sep 2026).

2025 Mercedes-Benz S-Class MPG

15–24 MPG · $2,000–$5,500/yr

Versus 2024: The most efficient configuration stays at 24 MPG. Its annual cost stays at $3,290.

Gas · 6.0L
Combined
15 MPG
Per year
$5,500
See gas configurations
Hybrid · 3.0L, 4.0L
Combined
20–24 MPG
Per year
$3,290–$4,110
See hybrid configurations
Plug-in hybrid · 3.0L, 4.0L
Gas-only combined
18–23 MPG
Per year
$2,000–$3,410

On electricity 49–63 MPGe, with 16–48 miles of electric range.

See plug-in hybrid configurations

Gas configurations (1)

2025 Mercedes-Benz S-Class gas configurations: EPA ratings and annual cost
TrimEngineDriveCityHwyComb.$/yr
Maybach S680 4matic (Most efficient) 6.0L 12-cyl turbo AWD 12 20 15 $5,500

1 configuration requires or recommends higher-octane gasoline and is costed at premium gasoline $5.36/gal (U.S. average, Sep 2026).

Hybrid configurations (3)

2025 Mercedes-Benz S-Class hybrid configurations: EPA ratings and annual cost
TrimEngineDriveCityHwyComb.$/yr
S500 4matic (Most efficient) 3.0L 6-cyl turbo supercharged AWD 21 31 24 $3,290
S580 4matic 4.0L 8-cyl turbo AWD 17 25 20 $4,080
S580 4matic Maybach 4.0L 8-cyl turbo AWD 16 27 20 $4,110

3 configurations require or recommend higher-octane gasoline and are costed at premium gasoline $5.36/gal (U.S. average, Sep 2026).

Plug-in hybrid configurations (2)

2025 Mercedes-Benz S-Class plug-in hybrid configurations: EPA ratings and annual cost
TrimDriveGas MPGElectric MPGeElectric range$/yr
S580e 4matic (Most efficient) AWD 23 63 48 mi $2,000
AMG S63 E Performance AWD 18 49 16 mi $3,410

Cost assumes EPA's utility factor: 40%–73% of miles are driven on electricity (residential electricity 18.3¢/kWh (U.S. average, Jul 2026)) and the rest on gasoline (premium gasoline $5.36/gal (U.S. average, Sep 2026)).

2024 Mercedes-Benz S-Class MPG

15–24 MPG · $3,290–$5,500/yr
Gas · 6.0L
Combined
15 MPG
Per year
$5,500
See gas configurations
Hybrid · 3.0L, 4.0L
Combined
21–24 MPG
Per year
$3,290–$3,860
See hybrid configurations

Gas configurations (1)

2024 Mercedes-Benz S-Class gas configurations: EPA ratings and annual cost
TrimEngineDriveCityHwyComb.$/yr
Maybach S680 4matic (Most efficient) 6.0L 12-cyl turbo AWD 12 20 15 $5,500

1 configuration requires or recommends higher-octane gasoline and is costed at premium gasoline $5.36/gal (U.S. average, Sep 2026).

Hybrid configurations (3)

2024 Mercedes-Benz S-Class hybrid configurations: EPA ratings and annual cost
TrimEngineDriveCityHwyComb.$/yr
S500 4matic (Most efficient) 3.0L 6-cyl turbo supercharged AWD 21 31 24 $3,290
S580 4matic 4.0L 8-cyl turbo AWD 18 27 21 $3,770
S580 4matic Maybach 4.0L 8-cyl turbo AWD 18 26 21 $3,860

3 configurations require or recommend higher-octane gasoline and are costed at premium gasoline $5.36/gal (U.S. average, Sep 2026).

Fuel cost by state

Yearly cost of the S500 4matic 3.0L 6-cyl turbo supercharged AWD: $4,210 in California and $3,060 in Texas, a $1,150 difference.

Gasoline prices: California: California state average; Washington: Washington state average; New York: New York state average; Florida: Florida state average; Texas: Texas state average (Sep 2026).
Fuel cost in every state

Similar cars

Closest combined MPG among MY2027 large car models.

EPA ratings: fueleconomy.gov file of Sep 29, 2026 · Prices: EIA regular gasoline, U.S. average, Sep 2026 ($4.36/gal) · 15,000 mi/yr, 55% city / 45% highway · How we calculate

Generations

Frequently asked questions

What gas mileage does the 2024-2027 Mercedes-Benz S-Class get?

EPA rates the 2024-2027 Mercedes-Benz S-Class at 14–24 MPG combined across 18 configurations and 4 model years. The most efficient version, the 2025 S500 4matic 3.0L 6-cyl turbo supercharged AWD, is rated 24 MPG (21 city, 31 highway). By powertrain: Gas: 14–15 MPG; Hybrid: 18–24 MPG; Plug-in hybrid: 18–23 MPG.

Which years had the best MPG in the 2024-2027 Mercedes-Benz S-Class?

The S500 4matic 3.0L 6-cyl turbo supercharged AWD reached the generation's best combined rating, 24 MPG, in 2024 and 2025. The lowest top rating, 23 MPG, was in 2026 and 2027.

Did EPA ratings change during the 2024-2027 Mercedes-Benz S-Class?

Yes. Ratings changed in 2025, 2026 and 2027.

How does the 2024-2027 Mercedes-Benz S-Class compare with the previous generation?

The previous generation (2022-2023 Mercedes-Benz S-Class) is rated 14–24 MPG combined and costs $1,970–$5,620 a year to fuel; the 2024-2027 model is rated 14–24 MPG and costs $2,000–$5,580 a year.

How much does it cost to fuel a 2027 Mercedes-Benz S-Class per year?

Driving 15,000 miles a year at premium gasoline $5.36/gal (U.S. average, Sep 2026), the S500 4matic 3.0L 6-cyl turbo supercharged AWD costs about $3,530 a year. Across all 4 configurations the cost runs $3,530–$5,580 a year. That is a $2,050 difference between the cheapest and the costliest configuration.

How much does it cost to drive a 2027 Mercedes-Benz S-Class 100 miles?

About $23.53 per 100 miles for the S500 4matic 3.0L 6-cyl turbo supercharged AWD at premium gasoline $5.36/gal (U.S. average, Sep 2026), and between $23.53 and $37.20 across all configurations. That is the annual cost over 15,000 miles divided by 150.

How does the 2027 Mercedes-Benz S-Class compare with other large car configurations?

The S500 4matic 3.0L 6-cyl turbo supercharged AWD costs about $3,530 a year to fuel, $2,270 more than the class median of $1,260, and less than 2 of 10 large car configurations. The comparison covers all 50 rated large car configurations for MY2027, not weighted by sales.

Is the 2027 Mercedes-Benz S-Class hybrid cheaper to fuel than the gas version?

Yes. The best hybrid (S500 4matic 3.0L 6-cyl turbo supercharged AWD) is rated 23 MPG against 14 MPG for the best gas version (Maybach S680 4matic 6.0L 12-cyl turbo AWD), 9 MPG more. At premium gasoline $5.36/gal (U.S. average, Sep 2026) that is $3,530 versus $5,580 a year, a saving of $2,050.

Is the 2027 Mercedes-Benz S-Class different from the 2026 model?

The most efficient configuration stays at 23 MPG. Its annual cost goes from $3,450 to $3,530, $80 more. EPA lists 4 configurations for 2027 against 4 configurations for 2026. See the 2026 Mercedes-Benz S-Class for that year.