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2021 Mercedes-Benz S-Class S350d Exclusive
Photo shows the 2021 model (previous generation): 2021 Mercedes-Benz S-Class S350d Exclusive. Photo: Chanokchon, CC BY-SA 4.0, via Wikimedia Commons
  • Newest year: 2023
  • Gas
  • Hybrid
  • Plug-in hybrid
  • Large cars

2022-2023 Mercedes-Benz S-Class MPG & Fuel Cost

2 model years · 14–24 MPG combined

23 MPG
Combined
20 MPG
City
28 MPG
Highway
Annual fuel cost · S500 4matic 3.0L 6-cyl AWD
$3,550

15,000 mi/yr · premium gasoline $5.36/gal (U.S. average, Sep 2026)

Cheaper to fuel than 4 of 10 large car configurations, MY2023. Ranked against all rated configurations, not sales-weighted.

2022-2023 Mercedes-Benz S-Class at a glance

The 2022-2023 Mercedes-Benz S-Class covers 2 model years in the EPA database (9 configurations in all), rated 14–24 MPG combined. The newest model year, 2023, costs about $3,550 a year to fuel for its most efficient version, the S500 4matic 3.0L 6-cyl AWD (23 MPG), at premium gasoline $5.36/gal (U.S. average, Sep 2026). Powertrains over the years: gas, hybrid and plug-in hybrid. EPA changed the ratings in 2023. The best combined rating in the generation, 24 MPG, was reached in 2022.

2022-2023 Mercedes-Benz S-Class by model year

2022-2023 Mercedes-Benz S-Class: EPA combined rating and yearly fuel cost for each model year
Model yearPowertrainsCombined$/yrEPA ratings
2023 Gas, Hybrid, Plug-in hybrid 14–23 MPG $1,970–$5,620 Ratings changed
2022 Gas, Hybrid 15–24 MPG $3,380–$5,430 First year

What the 2023 S500 4matic 3.0L 6-cyl AWD costs to drive

Per month

$296

$3,550 a year ÷ 12

Per 25 miles

$5.92

Per 100 miles

$23.67

Five years

$17,750

5 × the yearly cost, prices held at today's level

vs the large car median

$680more a year

Class median $2,870 a year, MY2023

Based on 15,000 miles a year and premium gasoline $5.36/gal (U.S. average, Sep 2026).

2023 Mercedes-Benz S-Class MPG

Versus 2022: The most efficient configuration moves from 24 to 23 MPG, down 1. Its annual cost goes from $3,380 to $3,550, $170 more.

Gas · 6.0L
Combined
14 MPG
Per year
$5,620
See gas configurations
Hybrid · 3.0L, 4.0L
Combined
18–23 MPG
Per year
$3,550–$4,450
See hybrid configurations
Plug-in hybrid · 3.0L
Gas-only combined
23 MPG
Per year
$1,970

On electricity 49 MPGe, with 56 miles of electric range.

See plug-in hybrid configurations

Gas configurations (1)

2023 Mercedes-Benz S-Class gas configurations: EPA ratings and annual cost
TrimEngineDriveCityHwyComb.$/yr
Maybach S680 4matic (Most efficient) 6.0L 12-cyl turbo AWD 12 20 14 $5,620

1 configuration requires or recommends higher-octane gasoline and is costed at premium gasoline $5.36/gal (U.S. average, Sep 2026).

Hybrid configurations (3)

2023 Mercedes-Benz S-Class hybrid configurations: EPA ratings and annual cost
TrimEngineDriveCityHwyComb.$/yr
S500 4matic (Most efficient) 3.0L 6-cyl AWD 20 28 23 $3,550
S580 4matic 4.0L 8-cyl turbo AWD 16 25 19 $4,150
S580 4matic Maybach 4.0L 8-cyl turbo AWD 15 25 18 $4,450

3 configurations require or recommend higher-octane gasoline and are costed at premium gasoline $5.36/gal (U.S. average, Sep 2026).

Plug-in hybrid configurations (1)

2023 Mercedes-Benz S-Class plug-in hybrid configurations: EPA ratings and annual cost
TrimDriveGas MPGElectric MPGeElectric range$/yr
S580e 4matic (Most efficient) AWD 23 49 56 mi $1,970

Cost assumes EPA's utility factor: 72% of miles are driven on electricity (residential electricity 18.3¢/kWh (U.S. average, Jul 2026)) and the rest on gasoline (premium gasoline $5.36/gal (U.S. average, Sep 2026)).

2022 Mercedes-Benz S-Class MPG

15–24 MPG · $3,380–$5,430/yr
Gas · 6.0L
Combined
15 MPG
Per year
$5,430
See gas configurations
Hybrid · 3.0L, 4.0L
Combined
18–24 MPG
Per year
$3,380–$4,380
See hybrid configurations

Gas configurations (1)

2022 Mercedes-Benz S-Class gas configurations: EPA ratings and annual cost
TrimEngineDriveCityHwyComb.$/yr
Maybach S680 4matic (Most efficient) 6.0L 12-cyl turbo AWD 12 21 15 $5,430

1 configuration requires or recommends higher-octane gasoline and is costed at premium gasoline $5.36/gal (U.S. average, Sep 2026).

Hybrid configurations (3)

2022 Mercedes-Benz S-Class hybrid configurations: EPA ratings and annual cost
TrimEngineDriveCityHwyComb.$/yr
S500 4matic (Most efficient) 3.0L 6-cyl AWD 21 30 24 $3,380
S580 4matic 4.0L 8-cyl turbo AWD 16 25 19 $4,150
S580 4matic Maybach 4.0L 8-cyl turbo AWD 15 24 18 $4,380

3 configurations require or recommend higher-octane gasoline and are costed at premium gasoline $5.36/gal (U.S. average, Sep 2026).

Fuel cost by state

Yearly cost of the S500 4matic 3.0L 6-cyl AWD: $4,230 in California and $3,070 in Texas, a $1,160 difference.

Gasoline prices: California: California state average; Washington: Washington state average; New York: New York state average; Florida: Florida state average; Texas: Texas state average (Sep 2026).
Fuel cost in every state

Similar cars

Closest combined MPG among MY2023 large car models.

EPA ratings: fueleconomy.gov file of Sep 29, 2026 · Prices: EIA regular gasoline, U.S. average, Sep 2026 ($4.36/gal) · EIA residential electricity, U.S. average, Jul 2026 (18.3¢/kWh) · 15,000 mi/yr, 55% city / 45% highway · How we calculate

Generations

Frequently asked questions

What gas mileage does the 2022-2023 Mercedes-Benz S-Class get?

EPA rates the 2022-2023 Mercedes-Benz S-Class at 14–24 MPG combined across 9 configurations and 2 model years. The most efficient version, the 2022 S500 4matic 3.0L 6-cyl AWD, is rated 24 MPG (21 city, 30 highway). By powertrain: Gas: 14–15 MPG; Hybrid: 18–24 MPG; Plug-in hybrid: 23 MPG.

Which years had the best MPG in the 2022-2023 Mercedes-Benz S-Class?

The S500 4matic 3.0L 6-cyl AWD reached the generation's best combined rating, 24 MPG, in 2022. The lowest top rating, 23 MPG, was in 2023.

Did EPA ratings change during the 2022-2023 Mercedes-Benz S-Class?

Yes. Ratings changed in 2023.

How does the 2022-2023 Mercedes-Benz S-Class compare with the previous generation?

The previous generation (2021 Mercedes-Benz S-Class) is rated 17–24 MPG combined and costs $3,390–$4,600 a year to fuel; the 2022-2023 model is rated 14–24 MPG and costs $1,970–$5,620 a year.

How much does it cost to fuel a 2023 Mercedes-Benz S-Class per year?

Driving 15,000 miles a year at premium gasoline $5.36/gal (U.S. average, Sep 2026), the S500 4matic 3.0L 6-cyl AWD costs about $3,550 a year. Across all 5 configurations the cost runs $1,970–$5,620 a year. That is a $3,650 difference between the cheapest and the costliest configuration.

How does the 2023 Mercedes-Benz S-Class compare with other large car configurations?

The S500 4matic 3.0L 6-cyl AWD costs about $3,550 a year to fuel, $680 more than the class median of $2,870, and less than 4 of 10 large car configurations. The comparison covers all 94 rated large car configurations for MY2023, not weighted by sales.

Is the 2023 Mercedes-Benz S-Class hybrid cheaper to fuel than the gas version?

Yes. The best hybrid (S500 4matic 3.0L 6-cyl AWD) is rated 23 MPG against 14 MPG for the best gas version (Maybach S680 4matic 6.0L 12-cyl turbo AWD), 9 MPG more. At premium gasoline $5.36/gal (U.S. average, Sep 2026) that is $3,550 versus $5,620 a year, a saving of $2,070.

How far does the 2023 Mercedes-Benz S-Class plug-in hybrid go on electricity?

EPA rates the electric range at 56 miles, with a total range of 470 miles when the gasoline engine helps. Once the battery is used, the car runs as a hybrid at 23 MPG. The S580e 4matic 3.0L 6-cyl turbo AWD costs about $1,970 a year, assuming EPA's utility factor of 72% of miles on electricity, at premium gasoline $5.36/gal (U.S. average, Sep 2026) + residential electricity 18.3¢/kWh (U.S. average, Jul 2026).

Is the 2023 Mercedes-Benz S-Class different from the 2022 model?

The most efficient configuration moves from 24 to 23 MPG, down 1. Its annual cost goes from $3,380 to $3,550, $170 more. EPA lists 5 configurations for 2023 against 4 configurations for 2022. See the 2022 Mercedes-Benz S-Class for that year.