- Newest year: 2006
- Gas
- Large cars
2000-2006 Mercedes-Benz S-Class MPG & Fuel Cost
7 model years · 13–19 MPG combined
15,000 mi/yr · premium gasoline $5.36/gal (U.S. average, Sep 2026)
Cheaper to fuel than 4 of 10 large car configurations, MY2006. Ranked against all rated configurations, not sales-weighted.
2000-2006 Mercedes-Benz S-Class at a glance
The 2000-2006 Mercedes-Benz S-Class covers 7 model years in the EPA database (36 configurations in all), rated 13–19 MPG combined. The newest model year, 2006, costs about $4,230 a year to fuel for its most efficient version, the S430 4.3L 8-cyl RWD (19 MPG), at premium gasoline $5.36/gal (U.S. average, Sep 2026). EPA changed the ratings in 2001, 2002, 2003, 2004, 2005 and 2006. The best combined rating in the generation, 19 MPG, was reached in 2004, 2005 and 2006.
EPA re-estimated ratings of 1985-2007 vehicles under its 2008 method; these figures are the re-estimated values.
2000-2006 Mercedes-Benz S-Class by model year
| Model year | Powertrains | Combined | $/yr | EPA ratings |
|---|---|---|---|---|
| 2006 | Gas | 13–19 MPG | $4,230–$6,180 | Ratings changed |
| 2005 | Gas | 13–19 MPG | $4,230–$6,180 | Ratings changed |
| 2004 | Gas | 13–19 MPG | $4,230–$6,180 | Ratings changed |
| 2003 | Gas | 14–18 MPG | $4,460–$5,740 | Ratings changed |
| 2002 | Gas | 16–18 MPG | $4,460–$5,020 | Ratings changed |
| 2001 | Gas | 16–18 MPG | $4,460–$5,020 | Ratings changed |
| 2000 | Gas | 17–18 MPG | $4,460–$4,730 | First year |
What the 2006 S430 4.3L 8-cyl RWD costs to drive
Per month
$353
$4,230 a year ÷ 12
Per 25 miles
$7.05
Per 100 miles
$28.20
Five years
$21,150
5 × the yearly cost, prices held at today's level
vs the large car median
$600more a year
Class median $3,630 a year, MY2006
Based on 15,000 miles a year and premium gasoline $5.36/gal (U.S. average, Sep 2026).
2006 Mercedes-Benz S-Class MPG
EPA re-estimated ratings of 1985-2007 vehicles under its 2008 method; these figures are the re-estimated values.
Versus 2005: The most efficient configuration stays at 19 MPG. Its annual cost stays at $4,230.
Gas configurations (8)
| Trim | Engine | Drive | City | Hwy | Comb. | $/yr |
|---|---|---|---|---|---|---|
| S430 (Most efficient) | 4.3L 8-cyl | RWD | 16 | 24 | 19 | $4,230 |
| S350 | 3.7L 6-cyl | RWD | 16 | 23 | 18 | $4,460 |
| S430 4matic | 4.3L 8-cyl | 4WD | 15 | 21 | 17 | $4,730 |
| S500 | 5.0L 8-cyl | RWD | 14 | 22 | 17 | $4,730 |
| S500 4matic | 5.0L 8-cyl | 4WD | 14 | 20 | 16 | $5,020 |
| S55 AMG | 5.4L 8-cyl supercharged | RWD | 13 | 20 | 16 | $5,020 |
| S65 AMG | 6.0L 12-cyl turbo | RWD | 11 | 18 | 14 | $5,740 |
| S600 | 5.5L 12-cyl turbo | RWD | 11 | 17 | 13 | $6,180 |
8 configurations require or recommend higher-octane gasoline and are costed at premium gasoline $5.36/gal (U.S. average, Sep 2026).
2005 Mercedes-Benz S-Class MPG
13–19 MPG · $4,230–$6,180/yr
EPA re-estimated ratings of 1985-2007 vehicles under its 2008 method; these figures are the re-estimated values.
Versus 2004: The most efficient configuration stays at 19 MPG. Its annual cost stays at $4,230.
Gas configurations (6)
| Trim | Engine | Drive | City | Hwy | Comb. | $/yr |
|---|---|---|---|---|---|---|
| S430 (Most efficient) | 4.3L 8-cyl | RWD | 16 | 24 | 19 | $4,230 |
| S430 4matic | 4.3L 8-cyl | 4WD | 15 | 21 | 17 | $4,730 |
| S500 | 5.0L 8-cyl | RWD | 14 | 22 | 17 | $4,730 |
| S500 4matic | 5.0L 8-cyl | 4WD | 14 | 20 | 16 | $5,020 |
| S55 AMG | 5.4L 8-cyl supercharged | RWD | 13 | 20 | 15 | $5,360 |
| S600 | 5.5L 12-cyl turbo | RWD | 11 | 17 | 13 | $6,180 |
6 configurations require or recommend higher-octane gasoline and are costed at premium gasoline $5.36/gal (U.S. average, Sep 2026).
2004 Mercedes-Benz S-Class MPG
13–19 MPG · $4,230–$6,180/yr
EPA re-estimated ratings of 1985-2007 vehicles under its 2008 method; these figures are the re-estimated values.
Versus 2003: The most efficient configuration moves from 18 to 19 MPG, up 1. Its annual cost goes from $4,460 to $4,230, $230 less.
Gas configurations (6)
| Trim | Engine | Drive | City | Hwy | Comb. | $/yr |
|---|---|---|---|---|---|---|
| S430 (Most efficient) | 4.3L 8-cyl | RWD | 16 | 24 | 19 | $4,230 |
| S430 4matic | 4.3L 8-cyl | 4WD | 15 | 21 | 17 | $4,730 |
| S500 | 5.0L 8-cyl | RWD | 14 | 22 | 17 | $4,730 |
| S500 4matic | 5.0L 8-cyl | 4WD | 14 | 20 | 16 | $5,020 |
| S55 AMG | 5.4L 8-cyl supercharged | RWD | 13 | 19 | 15 | $5,360 |
| S600 | 5.5L 12-cyl turbo | RWD | 11 | 17 | 13 | $6,180 |
6 configurations require or recommend higher-octane gasoline and are costed at premium gasoline $5.36/gal (U.S. average, Sep 2026).
2003 Mercedes-Benz S-Class MPG
14–18 MPG · $4,460–$5,740/yr
EPA re-estimated ratings of 1985-2007 vehicles under its 2008 method; these figures are the re-estimated values.
Versus 2002: The most efficient configuration stays at 18 MPG. Its annual cost stays at $4,460.
Gas configurations (6)
| Trim | Engine | Drive | City | Hwy | Comb. | $/yr |
|---|---|---|---|---|---|---|
| S430 (Most efficient) | 4.3L 8-cyl | RWD | 15 | 22 | 18 | $4,460 |
| S430 4matic | 4.3L 8-cyl | 4WD | 15 | 20 | 17 | $4,730 |
| S500 | 5.0L 8-cyl | RWD | 14 | 20 | 16 | $5,020 |
| S500 4matic | 5.0L 8-cyl | 4WD | 14 | 19 | 16 | $5,020 |
| S55 AMG | 5.0L 8-cyl supercharged | RWD | 13 | 20 | 15 | $5,360 |
| S600 | 5.5L 12-cyl turbo | RWD | 12 | 17 | 14 | $5,740 |
6 configurations require or recommend higher-octane gasoline and are costed at premium gasoline $5.36/gal (U.S. average, Sep 2026).
2002 Mercedes-Benz S-Class MPG
16–18 MPG · $4,460–$5,020/yr
EPA re-estimated ratings of 1985-2007 vehicles under its 2008 method; these figures are the re-estimated values.
Versus 2001: The most efficient configuration stays at 18 MPG. Its annual cost stays at $4,460.
Gas configurations (4)
| Trim | Engine | Drive | City | Hwy | Comb. | $/yr |
|---|---|---|---|---|---|---|
| S430 (Most efficient) | 4.3L 8-cyl | RWD | 15 | 22 | 18 | $4,460 |
| S500 | 5.0L 8-cyl | RWD | 14 | 21 | 17 | $4,730 |
| S55 AMG | 5.4L 8-cyl | RWD | 14 | 20 | 17 | $4,730 |
| S600 | 5.8L 12-cyl | RWD | 13 | 21 | 16 | $5,020 |
4 configurations require or recommend higher-octane gasoline and are costed at premium gasoline $5.36/gal (U.S. average, Sep 2026).
2001 Mercedes-Benz S-Class MPG
16–18 MPG · $4,460–$5,020/yr
EPA re-estimated ratings of 1985-2007 vehicles under its 2008 method; these figures are the re-estimated values.
Versus 2000: The most efficient configuration stays at 18 MPG. Its annual cost stays at $4,460.
Gas configurations (4)
| Trim | Engine | Drive | City | Hwy | Comb. | $/yr |
|---|---|---|---|---|---|---|
| S430 (Most efficient) | 4.3L 8-cyl | RWD | 16 | 23 | 18 | $4,460 |
| S500 | 5.0L 8-cyl | RWD | 14 | 21 | 17 | $4,730 |
| S55 AMG | 5.4L 8-cyl | RWD | 14 | 20 | 17 | $4,730 |
| S600 | 5.8L 12-cyl | RWD | 14 | 21 | 16 | $5,020 |
4 configurations require or recommend higher-octane gasoline and are costed at premium gasoline $5.36/gal (U.S. average, Sep 2026).
2000 Mercedes-Benz S-Class MPG
17–18 MPG · $4,460–$4,730/yr
EPA re-estimated ratings of 1985-2007 vehicles under its 2008 method; these figures are the re-estimated values.
Gas configurations (2)
| Trim | Engine | Drive | City | Hwy | Comb. | $/yr |
|---|---|---|---|---|---|---|
| S430 (Most efficient) | 4.3L 8-cyl | RWD | 15 | 22 | 18 | $4,460 |
| S500 | 5.0L 8-cyl | RWD | 15 | 21 | 17 | $4,730 |
2 configurations require or recommend higher-octane gasoline and are costed at premium gasoline $5.36/gal (U.S. average, Sep 2026).
Fuel cost by state
Yearly cost of the S430 4.3L 8-cyl RWD: $5,040 in California and $3,670 in Texas, a $1,370 difference.
- California $5,040
- Washington $4,740
- New York $4,180
- Florida $3,860
- Texas $3,670
Similar cars
Closest combined MPG among MY2006 large car models.
Generations
- 2000-2006 (W220)
- 2007-2013 (W221)
- 2014-2020 (W222)
- 2021
- 2022-2023
- 2024-2027*
Frequently asked questions
What gas mileage does the 2000-2006 Mercedes-Benz S-Class get?
EPA rates the 2000-2006 Mercedes-Benz S-Class at 13–19 MPG combined across 36 configurations and 7 model years. The most efficient version, the 2006 S430 4.3L 8-cyl RWD, is rated 19 MPG (16 city, 24 highway).
Which years had the best MPG in the 2000-2006 Mercedes-Benz S-Class?
The S430 4.3L 8-cyl RWD reached the generation's best combined rating, 19 MPG, in 2004, 2005 and 2006. The lowest top rating, 18 MPG, was in 2000, 2001, 2002 and 2003.
Did EPA ratings change during the 2000-2006 Mercedes-Benz S-Class?
Yes. Ratings changed in 2001, 2002, 2003, 2004, 2005 and 2006.
How much does it cost to fuel a 2006 Mercedes-Benz S-Class per year?
Driving 15,000 miles a year at premium gasoline $5.36/gal (U.S. average, Sep 2026), the S430 4.3L 8-cyl RWD costs about $4,230 a year. Across all 8 configurations the cost runs $4,230–$6,180 a year. That is a $1,950 difference between the cheapest and the costliest configuration.
How much does it cost to drive a 2006 Mercedes-Benz S-Class 100 miles?
About $28.20 per 100 miles for the S430 4.3L 8-cyl RWD at premium gasoline $5.36/gal (U.S. average, Sep 2026), and between $28.20 and $41.20 across all configurations. That is the annual cost over 15,000 miles divided by 150.
Is the 2006 Mercedes-Benz S-Class more efficient in the city or on the highway?
The S430 4.3L 8-cyl RWD is rated 16 city and 24 highway MPG, so it is more efficient on the highway, by 8 MPG.
How does the 2006 Mercedes-Benz S-Class compare with other large car configurations?
The S430 4.3L 8-cyl RWD costs about $4,230 a year to fuel, $600 more than the class median of $3,630, and less than 4 of 10 large car configurations. The comparison covers all 73 rated large car configurations for MY2006, not weighted by sales.
Is the 2006 Mercedes-Benz S-Class different from the 2005 model?
The most efficient configuration stays at 19 MPG. Its annual cost stays at $4,230. EPA lists 8 configurations for 2006 against 6 configurations for 2005. See the 2005 Mercedes-Benz S-Class for that year.