- Newest year: 2021
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- Hybrid
- Small cars
2021 Mercedes-Benz S-Class MPG & Fuel Cost
7 configurations · 17–24 MPG combined
15,000 mi/yr · premium gasoline $5.36/gal (U.S. average, Sep 2026)
Cheaper to fuel than 2 of 10 small car configurations, MY2021. Ranked against all rated configurations, not sales-weighted.
2021 Mercedes-Benz S-Class at a glance
The 2021 Mercedes-Benz S-Class has 7 configurations in the EPA database, rated 17–24 MPG combined. The most efficient is the S500 4matic 3.0L 6-cyl 4WD at 24 MPG, which costs about $3,390 a year to fuel at premium gasoline $5.36/gal (U.S. average, Sep 2026). Annual fuel cost across the configurations runs from $3,390 to $4,600, a $1,210 difference. The S560 Convertible 4.0L 8-cyl turbo RWD costs less to fuel than 2 of 10 small car configurations rated for MY2021 (class median $3,210 a year).
What the 2021 S560 Convertible 4.0L 8-cyl turbo RWD costs to drive
Per month
$343
$4,110 a year ÷ 12
Per 25 miles
$6.85
Per 100 miles
$27.40
Five years
$20,550
5 × the yearly cost, prices held at today's level
vs the small car median
$900more a year
Class median $3,210 a year, MY2021
Based on 15,000 miles a year and premium gasoline $5.36/gal (U.S. average, Sep 2026).
2021 Mercedes-Benz S-Class MPG
Gas configurations (4)
| Trim | Engine | Drive | City | Hwy | Comb. | $/yr |
|---|---|---|---|---|---|---|
| S560 Convertible (Most efficient) | 4.0L 8-cyl turbo | RWD | 16 | 26 | 20 | $4,110 |
| S560 4matic Coupe | 4.0L 8-cyl turbo | 4WD | 16 | 26 | 20 | $4,110 |
| AMG S63 4matic Plus Coupe | 4.0L 8-cyl turbo | 4WD | 16 | 26 | 19 | $4,250 |
| AMG S63 4matic Plus Convertible | 4.0L 8-cyl turbo | 4WD | 14 | 24 | 17 | $4,600 |
4 configurations require or recommend higher-octane gasoline and are costed at premium gasoline $5.36/gal (U.S. average, Sep 2026).
Hybrid configurations (3)
| Trim | Engine | Drive | City | Hwy | Comb. | $/yr |
|---|---|---|---|---|---|---|
| S500 4matic (Most efficient) | 3.0L 6-cyl | 4WD | 20 | 29 | 24 | $3,390 |
| S580 4matic | 4.0L 8-cyl turbo | 4WD | 17 | 25 | 20 | $4,110 |
| S580 4matic Maybach | 4.0L 8-cyl turbo | 4WD | 16 | 24 | 19 | $4,270 |
3 configurations require or recommend higher-octane gasoline and are costed at premium gasoline $5.36/gal (U.S. average, Sep 2026).
Fuel cost by state
Yearly cost of the S560 Convertible 4.0L 8-cyl turbo RWD: $4,900 in California and $3,560 in Texas, a $1,340 difference.
- California $4,900
- Washington $4,600
- New York $4,050
- Florida $3,750
- Texas $3,560
Similar cars
Closest combined MPG among MY2021 small car models.
Generations
Frequently asked questions
How does the 2021 Mercedes-Benz S-Class compare with the previous generation?
The previous generation (2014-2020 Mercedes-Benz S-Class) is rated 15–22 MPG combined and costs $2,510–$5,280 a year to fuel; the 2021 model is rated 17–24 MPG and costs $3,390–$4,600 a year.
What gas mileage does the 2021 Mercedes-Benz S-Class get?
EPA rates the 2021 Mercedes-Benz S-Class at 17–24 MPG combined across 7 configurations. The most efficient, the S500 4matic 3.0L 6-cyl 4WD, is rated 24 MPG combined (20 city / 29 highway). By powertrain: Gas: 17–20 MPG; Hybrid: 19–24 MPG.
How much does it cost to fuel a 2021 Mercedes-Benz S-Class per year?
Driving 15,000 miles a year at premium gasoline $5.36/gal (U.S. average, Sep 2026), the S560 Convertible 4.0L 8-cyl turbo RWD costs about $4,110 a year. Across all 7 configurations the cost runs $3,390–$4,600 a year. That is a $1,210 difference between the cheapest and the costliest configuration.
How much does it cost to drive a 2021 Mercedes-Benz S-Class 100 miles?
About $27.40 per 100 miles for the S560 Convertible 4.0L 8-cyl turbo RWD at premium gasoline $5.36/gal (U.S. average, Sep 2026), and between $22.60 and $30.67 across all configurations. That is the annual cost over 15,000 miles divided by 150.
Is the 2021 Mercedes-Benz S-Class more efficient in the city or on the highway?
The S560 Convertible 4.0L 8-cyl turbo RWD is rated 16 city and 26 highway MPG, so it is more efficient on the highway, by 10 MPG.
How does the 2021 Mercedes-Benz S-Class compare with other small car configurations?
The S560 Convertible 4.0L 8-cyl turbo RWD costs about $4,110 a year to fuel, $900 more than the class median of $3,210, and less than 2 of 10 small car configurations. The comparison covers all 298 rated small car configurations for MY2021, not weighted by sales.
Is the 2021 Mercedes-Benz S-Class hybrid cheaper to fuel than the gas version?
Yes. The best hybrid (S500 4matic 3.0L 6-cyl 4WD) is rated 24 MPG against 20 MPG for the best gas version (S560 Convertible 4.0L 8-cyl turbo RWD), 4 MPG more. At premium gasoline $5.36/gal (U.S. average, Sep 2026) that is $3,390 versus $4,110 a year, a saving of $720.
Is the 2021 Mercedes-Benz S-Class different from the 2020 model?
The most efficient configuration moves from 22 to 24 MPG, up 2. Its annual cost goes from $3,660 to $3,390, $270 less. EPA lists 7 configurations for 2021 against 13 configurations for 2020. See the 2020 Mercedes-Benz S-Class for that year.