- Newest year: 2016
- Gas
- Midsize cars
2010-2016 Mercedes-Benz E-Class MPG & Fuel Cost
7 model years · 15–26 MPG combined
15,000 mi/yr · premium gasoline $5.36/gal (U.S. average, Sep 2026)
Cheaper to fuel than 3 of 10 midsize car configurations, MY2016. Ranked against all rated configurations, not sales-weighted.
2010-2016 Mercedes-Benz E-Class at a glance
The 2010-2016 Mercedes-Benz E-Class covers 7 model years in the EPA database (112 configurations in all), rated 15–26 MPG combined. The newest model year, 2016, costs about $3,420 a year to fuel for its most efficient version, the E400 3.0L 6-cyl turbo RWD (23 MPG), at premium gasoline $5.36/gal (U.S. average, Sep 2026). Powertrains over the years: gas and hybrid. EPA changed the ratings in 2011, 2012, 2013, 2014, 2015 and 2016. The best combined rating in the generation, 26 MPG, was reached in 2013 and 2014.
2010-2016 Mercedes-Benz E-Class by model year
| Model year | Powertrains | Combined | $/yr | EPA ratings |
|---|---|---|---|---|
| 2016 | Gas | 18–23 MPG | $3,420–$4,540 | Ratings changed |
| 2015 | Gas, Hybrid | 18–25 MPG | $3,160–$4,540 | Ratings changed |
| 2014 | Gas, Hybrid | 17–26 MPG | $3,040–$4,590 | Ratings changed |
| 2013 | Gas, Hybrid | 18–26 MPG | $3,040–$4,420 | Ratings changed |
| 2012 | Gas | 18–23 MPG | $3,490–$4,420 | Ratings changed |
| 2011 | Gas | 15–20 MPG | $3,990–$5,280 | Ratings changed |
| 2010 | Gas | 15–21 MPG | $3,830–$5,360 | First year |
What the 2016 E400 3.0L 6-cyl turbo RWD costs to drive
Per month
$285
$3,420 a year ÷ 12
Per 25 miles
$5.70
Per 100 miles
$22.80
Five years
$17,100
5 × the yearly cost, prices held at today's level
vs the midsize car median
$540more a year
Class median $2,880 a year, MY2016
Based on 15,000 miles a year and premium gasoline $5.36/gal (U.S. average, Sep 2026).
2016 Mercedes-Benz E-Class MPG
Versus 2015: The most efficient configuration moves from 25 to 23 MPG, down 2. Its annual cost goes from $3,160 to $3,420, $260 more.
Gas configurations (16)
| Trim | Engine | Drive | City | Hwy | Comb. | $/yr |
|---|---|---|---|---|---|---|
| E400 (Most efficient) | 3.0L 6-cyl turbo | RWD | 20 | 29 | 23 | $3,420 |
| E400 Coupe | 3.0L 6-cyl turbo | RWD | 20 | 29 | 23 | $3,430 |
| E400 Convertible | 3.0L 6-cyl turbo | RWD | 20 | 29 | 23 | $3,430 |
| E350 3.5L 6-cyl RWD Automatic 7-spd | 3.5L 6-cyl | RWD | 20 | 29 | 23 | $3,430 |
| E350 3.5L 6-cyl RWD Automatic 7-spd | 3.5L 6-cyl | RWD | 20 | 28 | 23 | $3,450 |
| E350 4matic 3.5L 6-cyl 4WD Automatic 7-spd | 3.5L 6-cyl | 4WD | 20 | 27 | 23 | $3,480 |
| E350 4matic 3.5L 6-cyl 4WD Automatic 7-spd | 3.5L 6-cyl | 4WD | 20 | 27 | 23 | $3,480 |
| E400 4matic Coupe | 3.0L 6-cyl turbo | 4WD | 20 | 28 | 23 | $3,520 |
| E400 4matic | 3.0L 6-cyl turbo | 4WD | 20 | 27 | 22 | $3,580 |
| E350 4matic (wagon) | 3.5L 6-cyl | 4WD | 20 | 26 | 22 | $3,590 |
Show 6 more configurations
| Trim | Engine | Drive | City | Hwy | Comb. | $/yr |
|---|---|---|---|---|---|---|
| E550 Coupe | 4.7L 8-cyl turbo | RWD | 18 | 26 | 21 | $3,890 |
| E550 4matic | 4.7L 8-cyl turbo | 4WD | 18 | 24 | 21 | $3,900 |
| E550 Convertible | 4.7L 8-cyl turbo | RWD | 17 | 25 | 20 | $3,990 |
| AMG E63 4matic | 5.5L 8-cyl turbo | 4WD | 16 | 23 | 19 | $4,320 |
| AMG E63 S 4matic | 5.5L 8-cyl turbo | 4WD | 15 | 22 | 18 | $4,540 |
| AMG E63 S 4matic (wagon) | 5.5L 8-cyl turbo | 4WD | 16 | 21 | 18 | $4,540 |
16 configurations require or recommend higher-octane gasoline and are costed at premium gasoline $5.36/gal (U.S. average, Sep 2026).
Flex-fuel (E85) configurations are costed on gasoline, not E85.
2015 Mercedes-Benz E-Class MPG
18–25 MPG · $3,160–$4,540/yr
Versus 2014: The most efficient configuration moves from 26 to 25 MPG, down 1. Its annual cost goes from $3,040 to $3,160, $120 more.
Gas configurations (18)
| Trim | Engine | Drive | City | Hwy | Comb. | $/yr |
|---|---|---|---|---|---|---|
| E400 Coupe (Most efficient) | 3.0L 6-cyl turbo | RWD | 20 | 29 | 23 | $3,430 |
| E400 Convertible | 3.0L 6-cyl turbo | RWD | 20 | 29 | 23 | $3,430 |
| E400 | 3.0L 6-cyl turbo | RWD | 20 | 29 | 23 | $3,440 |
| E350 3.5L 6-cyl RWD Automatic 7-spd | 3.5L 6-cyl | RWD | 20 | 28 | 23 | $3,450 |
| E350 3.5L 6-cyl RWD Automatic 7-spd | 3.5L 6-cyl | RWD | 20 | 28 | 23 | $3,450 |
| E350 4matic 3.5L 6-cyl 4WD Automatic 7-spd | 3.5L 6-cyl | 4WD | 20 | 27 | 23 | $3,480 |
Show 8 more configurations
| Trim | Engine | Drive | City | Hwy | Comb. | $/yr |
|---|---|---|---|---|---|---|
| E350 4matic 3.5L 6-cyl 4WD Automatic 7-spd | 3.5L 6-cyl | 4WD | 20 | 27 | 23 | $3,480 |
| E400 4matic Coupe | 3.0L 6-cyl turbo | 4WD | 20 | 28 | 23 | $3,520 |
| E350 Convertible | 3.5L 6-cyl | RWD | 20 | 28 | 23 | $3,570 |
| E400 4matic | 3.0L 6-cyl turbo | 4WD | 20 | 27 | 22 | $3,580 |
| E350 Coupe | 3.5L 6-cyl | RWD | 19 | 28 | 22 | $3,590 |
| E350 4matic (wagon) | 3.5L 6-cyl | 4WD | 20 | 26 | 22 | $3,590 |
| E400 4matic (station wagon) | 3.0L 6-cyl turbo | 4WD | 19 | 26 | 22 | $3,710 |
| E550 Coupe | 4.7L 8-cyl turbo | RWD | 18 | 26 | 21 | $3,900 |
| E550 Convertible | 4.7L 8-cyl turbo | RWD | 17 | 25 | 20 | $3,990 |
| E63 AMG 4matic | 5.5L 8-cyl turbo | 4WD | 16 | 23 | 19 | $4,320 |
| E63 AMG S 4matic | 5.5L 8-cyl turbo | 4WD | 15 | 22 | 18 | $4,530 |
| E63 AMG S 4matic (wagon) | 5.5L 8-cyl turbo | 4WD | 16 | 21 | 18 | $4,540 |
18 configurations require or recommend higher-octane gasoline and are costed at premium gasoline $5.36/gal (U.S. average, Sep 2026).
Flex-fuel (E85) configurations are costed on gasoline, not E85.
Hybrid configurations (1)
| Trim | Engine | Drive | City | Hwy | Comb. | $/yr |
|---|---|---|---|---|---|---|
| E400 Hybrid (Most efficient) | 3.5L 6-cyl | RWD | 24 | 28 | 25 | $3,160 |
1 configuration requires or recommends higher-octane gasoline and is costed at premium gasoline $5.36/gal (U.S. average, Sep 2026).
2014 Mercedes-Benz E-Class MPG
17–26 MPG · $3,040–$4,590/yr
Versus 2013: The most efficient configuration stays at 26 MPG. Its annual cost stays at $3,040.
Gas configurations (24)
| Trim | Engine | Drive | City | Hwy | Comb. | $/yr |
|---|---|---|---|---|---|---|
| E350 3.5L 6-cyl RWD Automatic 7-spd (Most efficient) | 3.5L 6-cyl | RWD | 20 | 30 | 24 | $3,380 |
| E350 Coupe 3.5L 6-cyl RWD Automatic 7-spd | 3.5L 6-cyl | RWD | 20 | 30 | 24 | $3,380 |
| E350 3.5L 6-cyl RWD Automatic 7-spd | 3.5L 6-cyl | RWD | 20 | 29 | 23 | $3,470 |
| E350 4matic 3.5L 6-cyl 4WD Automatic 7-spd | 3.5L 6-cyl | 4WD | 20 | 28 | 23 | $3,470 |
| E350 4matic 3.5L 6-cyl 4WD Automatic 7-spd | 3.5L 6-cyl | 4WD | 20 | 27 | 23 | $3,480 |
| E350 3.5L 6-cyl RWD Automatic 7-spd | 3.5L 6-cyl | RWD | 20 | 28 | 23 | $3,490 |
Show 14 more configurations
| Trim | Engine | Drive | City | Hwy | Comb. | $/yr |
|---|---|---|---|---|---|---|
| E350 4matic Coupe 3.5L 6-cyl 4WD Automatic 7-spd | 3.5L 6-cyl | 4WD | 20 | 28 | 23 | $3,490 |
| E350 Coupe 3.5L 6-cyl RWD Automatic 7-spd | 3.5L 6-cyl | RWD | 20 | 28 | 23 | $3,500 |
| E350 Coupe 3.5L 6-cyl RWD Automatic 7-spd | 3.5L 6-cyl | RWD | 20 | 28 | 23 | $3,520 |
| E350 4matic Coupe 3.5L 6-cyl 4WD Automatic 7-spd | 3.5L 6-cyl | 4WD | 20 | 28 | 23 | $3,550 |
| E350 4matic Coupe 3.5L 6-cyl 4WD Automatic 7-spd | 3.5L 6-cyl | 4WD | 20 | 28 | 23 | $3,550 |
| E350 Convertible 3.5L 6-cyl RWD Automatic 7-spd | 3.5L 6-cyl | RWD | 20 | 28 | 23 | $3,570 |
| E350 4matic (wagon) | 3.5L 6-cyl | 4WD | 20 | 26 | 22 | $3,590 |
| E350 4matic 3.5L 6-cyl 4WD Automatic 7-spd | 3.5L 6-cyl | 4WD | 20 | 27 | 22 | $3,610 |
| E350 Convertible 3.5L 6-cyl RWD Automatic 7-spd | 3.5L 6-cyl | RWD | 19 | 28 | 22 | $3,610 |
| E550 Coupe | 4.7L 8-cyl turbo | RWD | 18 | 26 | 21 | $3,900 |
| E550 4matic | 4.7L 8-cyl turbo | 4WD | 18 | 24 | 21 | $3,910 |
| E550 Convertible | 4.7L 8-cyl turbo | RWD | 17 | 25 | 20 | $4,000 |
| E63 AMG | 5.5L 8-cyl turbo | RWD | 16 | 24 | 19 | $4,310 |
| E63 AMG S | 5.5L 8-cyl turbo | RWD | 16 | 24 | 19 | $4,310 |
| E63 AMG 4matic | 5.5L 8-cyl turbo | 4WD | 16 | 23 | 19 | $4,320 |
| E63 AMG S 4matic | 5.5L 8-cyl turbo | 4WD | 15 | 22 | 18 | $4,530 |
| E63 AMG S 4matic (wagon) | 5.5L 8-cyl turbo | 4WD | 16 | 21 | 18 | $4,540 |
| E63 AMG 4matic (wagon) | 5.5L 8-cyl turbo | 4WD | 15 | 21 | 17 | $4,590 |
24 configurations require or recommend higher-octane gasoline and are costed at premium gasoline $5.36/gal (U.S. average, Sep 2026).
Flex-fuel (E85) configurations are costed on gasoline, not E85.
Hybrid configurations (1)
| Trim | Engine | Drive | City | Hwy | Comb. | $/yr |
|---|---|---|---|---|---|---|
| E400 Hybrid (Most efficient) | 3.5L 6-cyl | RWD | 24 | 30 | 26 | $3,040 |
1 configuration requires or recommends higher-octane gasoline and is costed at premium gasoline $5.36/gal (U.S. average, Sep 2026).
2013 Mercedes-Benz E-Class MPG
18–26 MPG · $3,040–$4,420/yr
Versus 2012: The most efficient configuration moves from 23 to 26 MPG, up 3. Its annual cost goes from $3,490 to $3,040, $450 less.
Gas configurations (20)
| Trim | Engine | Drive | City | Hwy | Comb. | $/yr |
|---|---|---|---|---|---|---|
| E350 3.5L 6-cyl RWD Automatic 7-spd (Most efficient) | 3.5L 6-cyl | RWD | 20 | 29 | 23 | $3,480 |
| E350 3.5L 6-cyl RWD Automatic 7-spd | 3.5L 6-cyl | RWD | 20 | 29 | 23 | $3,480 |
| E350 3.5L 6-cyl RWD Automatic 7-spd | 3.5L 6-cyl | RWD | 19 | 29 | 23 | $3,520 |
| E350 Coupe 3.5L 6-cyl RWD Automatic 7-spd | 3.5L 6-cyl | RWD | 19 | 29 | 23 | $3,530 |
| E350 Coupe 3.5L 6-cyl RWD Automatic 7-spd | 3.5L 6-cyl | RWD | 20 | 28 | 23 | $3,560 |
| E350 Coupe 3.5L 6-cyl RWD Automatic 7-spd | 3.5L 6-cyl | RWD | 20 | 28 | 23 | $3,560 |
Show 10 more configurations
| Trim | Engine | Drive | City | Hwy | Comb. | $/yr |
|---|---|---|---|---|---|---|
| E350 4matic Coupe 3.5L 6-cyl 4WD Automatic 7-spd | 3.5L 6-cyl | 4WD | 19 | 29 | 22 | $3,580 |
| E350 4matic 3.5L 6-cyl 4WD Automatic 7-spd | 3.5L 6-cyl | 4WD | 19 | 28 | 22 | $3,600 |
| E350 Convertible 3.5L 6-cyl RWD Automatic 7-spd | 3.5L 6-cyl | RWD | 19 | 28 | 22 | $3,620 |
| E350 Convertible 3.5L 6-cyl RWD Automatic 7-spd | 3.5L 6-cyl | RWD | 19 | 28 | 22 | $3,620 |
| E350 4matic 3.5L 6-cyl 4WD Automatic 7-spd | 3.5L 6-cyl | 4WD | 19 | 28 | 22 | $3,620 |
| E350 4Matic | 3.5L 6-cyl | 4WD | 19 | 28 | 22 | $3,620 |
| E350 4matic Coupe 3.5L 6-cyl 4WD Automatic 7-spd | 3.5L 6-cyl | 4WD | 19 | 27 | 22 | $3,680 |
| E350 4matic Coupe 3.5L 6-cyl 4WD Automatic 7-spd | 3.5L 6-cyl | 4WD | 19 | 27 | 22 | $3,680 |
| E350 4matic (wagon) | 3.5L 6-cyl | 4WD | 19 | 27 | 22 | $3,740 |
| E550 Coupe | 4.7L 8-cyl turbo | RWD | 17 | 27 | 21 | $3,910 |
| E550 4matic | 4.7L 8-cyl turbo | 4WD | 16 | 26 | 20 | $4,110 |
| E550 Convertible | 4.7L 8-cyl turbo | RWD | 16 | 25 | 19 | $4,140 |
| E63 AMG | 5.5L 8-cyl turbo | RWD | 16 | 24 | 19 | $4,310 |
| E63 AMG (wagon) | 5.5L 8-cyl turbo | RWD | 15 | 23 | 18 | $4,420 |
20 configurations require or recommend higher-octane gasoline and are costed at premium gasoline $5.36/gal (U.S. average, Sep 2026).
Flex-fuel (E85) configurations are costed on gasoline, not E85.
Hybrid configurations (1)
| Trim | Engine | Drive | City | Hwy | Comb. | $/yr |
|---|---|---|---|---|---|---|
| E400 Hybrid (Most efficient) | 3.5L 6-cyl | RWD | 24 | 30 | 26 | $3,040 |
1 configuration requires or recommends higher-octane gasoline and is costed at premium gasoline $5.36/gal (U.S. average, Sep 2026).
2012 Mercedes-Benz E-Class MPG
18–23 MPG · $3,490–$4,420/yr
Versus 2011: The most efficient configuration moves from 20 to 23 MPG, up 3. Its annual cost goes from $3,990 to $3,490, $500 less.
Gas configurations (14)
| Trim | Engine | Drive | City | Hwy | Comb. | $/yr |
|---|---|---|---|---|---|---|
| E350 (Most efficient) | 3.5L 6-cyl | RWD | 20 | 30 | 23 | $3,490 |
| E350 Coupe 3.5L 6-cyl RWD Automatic 7-spd | 3.5L 6-cyl | RWD | 20 | 28 | 23 | $3,560 |
| E350 4matic | 3.5L 6-cyl | 4WD | 19 | 28 | 22 | $3,590 |
| E350 Coupe 3.5L 6-cyl RWD Automatic 7-spd | 3.5L 6-cyl | RWD | 19 | 28 | 22 | $3,600 |
| E350 Convertible 3.5L 6-cyl RWD Automatic 7-spd | 3.5L 6-cyl | RWD | 19 | 28 | 22 | $3,620 |
| E350 Convertible 3.5L 6-cyl RWD Automatic 7-spd | 3.5L 6-cyl | RWD | 19 | 28 | 22 | $3,620 |
Show 4 more configurations
| Trim | Engine | Drive | City | Hwy | Comb. | $/yr |
|---|---|---|---|---|---|---|
| E350 4matic Coupe 3.5L 6-cyl 4WD Automatic 7-spd | 3.5L 6-cyl | 4WD | 19 | 27 | 22 | $3,670 |
| E350 4matic Coupe 3.5L 6-cyl 4WD Automatic 7-spd | 3.5L 6-cyl | 4WD | 19 | 27 | 22 | $3,680 |
| E350 4matic (wagon) | 3.5L 6-cyl | 4WD | 19 | 27 | 22 | $3,740 |
| E550 Coupe | 4.7L 8-cyl turbo | RWD | 17 | 27 | 21 | $3,910 |
| E550 4matic | 4.7L 8-cyl turbo | 4WD | 16 | 26 | 20 | $4,110 |
| E550 Convertible | 4.7L 8-cyl turbo | RWD | 16 | 25 | 19 | $4,140 |
| E63 AMG | 5.5L 8-cyl turbo | RWD | 16 | 24 | 19 | $4,310 |
| E63 AMG (wagon) | 5.5L 8-cyl turbo | RWD | 15 | 23 | 18 | $4,420 |
14 configurations require or recommend higher-octane gasoline and are costed at premium gasoline $5.36/gal (U.S. average, Sep 2026).
Flex-fuel (E85) configurations are costed on gasoline, not E85.
2011 Mercedes-Benz E-Class MPG
15–20 MPG · $3,990–$5,280/yr
Versus 2010: The most efficient configuration moves from 21 to 20 MPG, down 1. Its annual cost goes from $3,830 to $3,990, $160 more.
Gas configurations (10)
| Trim | Engine | Drive | City | Hwy | Comb. | $/yr |
|---|---|---|---|---|---|---|
| E350 Coupe (Most efficient) | 3.5L 6-cyl | RWD | 17 | 26 | 20 | $3,990 |
| E350 | 3.5L 6-cyl | RWD | 17 | 25 | 20 | $4,020 |
| E350 Convertible | 3.5L 6-cyl | RWD | 17 | 25 | 20 | $4,060 |
| E350 4matic | 3.5L 6-cyl | 4WD | 17 | 24 | 19 | $4,190 |
| E350 4matic (wagon) | 3.5L 6-cyl | 4WD | 16 | 23 | 19 | $4,260 |
| E550 | 5.5L 8-cyl | RWD | 15 | 23 | 18 | $4,500 |
Show 0 more configurations
| Trim | Engine | Drive | City | Hwy | Comb. | $/yr |
|---|---|---|---|---|---|---|
| E550 Coupe | 5.5L 8-cyl | RWD | 15 | 23 | 18 | $4,510 |
| E550 4matic | 5.5L 8-cyl | 4WD | 15 | 23 | 18 | $4,550 |
| E550 Convertible | 5.5L 8-cyl | RWD | 15 | 22 | 17 | $4,630 |
| E63 AMG | 6.2L 8-cyl | RWD | 13 | 20 | 15 | $5,280 |
10 configurations require or recommend higher-octane gasoline and are costed at premium gasoline $5.36/gal (U.S. average, Sep 2026).
2010 Mercedes-Benz E-Class MPG
15–21 MPG · $3,830–$5,360/yr
Gas configurations (7)
| Trim | Engine | Drive | City | Hwy | Comb. | $/yr |
|---|---|---|---|---|---|---|
| E350 (Most efficient) | 3.5L 6-cyl | RWD | 18 | 26 | 21 | $3,830 |
| E350 Coupe | 3.5L 6-cyl | RWD | 17 | 26 | 20 | $4,020 |
| E350 4matic | 3.5L 6-cyl | 4WD | 17 | 24 | 19 | $4,230 |
| E550 Coupe | 5.5L 8-cyl | RWD | 15 | 23 | 18 | $4,460 |
| E550 | 5.5L 8-cyl | RWD | 16 | 24 | 18 | $4,460 |
| E550 4matic | 5.5L 8-cyl | 4WD | 15 | 23 | 18 | $4,460 |
Show 0 more configurations
| Trim | Engine | Drive | City | Hwy | Comb. | $/yr |
|---|---|---|---|---|---|---|
| E63 AMG | 6.3L 8-cyl | RWD | 13 | 20 | 15 | $5,360 |
7 configurations require or recommend higher-octane gasoline and are costed at premium gasoline $5.36/gal (U.S. average, Sep 2026).
Fuel cost by state
Yearly cost of the E400 3.0L 6-cyl turbo RWD: $4,080 in California and $2,970 in Texas, a $1,110 difference.
- California $4,080
- Washington $3,840
- New York $3,380
- Florida $3,120
- Texas $2,970
Similar cars
Closest combined MPG among MY2016 midsize car models.
Generations
- 2000-2002 (W210)
- 2003-2009 (W211)
- 2010-2016 (W212)
- 2017-2023 (W213)
- 2024-2027* (W214)
Frequently asked questions
What gas mileage does the 2010-2016 Mercedes-Benz E-Class get?
EPA rates the 2010-2016 Mercedes-Benz E-Class at 15–26 MPG combined across 112 configurations and 7 model years. The most efficient version, the 2014 E400 Hybrid 3.5L 6-cyl RWD, is rated 26 MPG (24 city, 30 highway). By powertrain: Gas: 15–24 MPG; Hybrid: 25–26 MPG.
Which years had the best MPG in the 2010-2016 Mercedes-Benz E-Class?
The E400 Hybrid 3.5L 6-cyl RWD reached the generation's best combined rating, 26 MPG, in 2013 and 2014. The lowest top rating, 20 MPG, was in 2011.
Did EPA ratings change during the 2010-2016 Mercedes-Benz E-Class?
Yes. Ratings changed in 2011, 2012, 2013, 2014, 2015 and 2016.
How does the 2010-2016 Mercedes-Benz E-Class compare with the previous generation?
The previous generation (2003-2009 Mercedes-Benz E-Class) is rated 14–27 MPG combined and costs $3,500–$5,740 a year to fuel; the 2010-2016 model is rated 15–26 MPG and costs $3,040–$5,360 a year.
How much does it cost to fuel a 2016 Mercedes-Benz E-Class per year?
Driving 15,000 miles a year at premium gasoline $5.36/gal (U.S. average, Sep 2026), the E400 3.0L 6-cyl turbo RWD costs about $3,420 a year. Across all 16 configurations the cost runs $3,420–$4,540 a year. That is a $1,120 difference between the cheapest and the costliest configuration.
How much does it cost to drive a 2016 Mercedes-Benz E-Class 100 miles?
About $22.80 per 100 miles for the E400 3.0L 6-cyl turbo RWD at premium gasoline $5.36/gal (U.S. average, Sep 2026), and between $22.80 and $30.27 across all configurations. That is the annual cost over 15,000 miles divided by 150.
Is the 2016 Mercedes-Benz E-Class more efficient in the city or on the highway?
The E400 3.0L 6-cyl turbo RWD is rated 20 city and 29 highway MPG, so it is more efficient on the highway, by 9 MPG.
How does the 2016 Mercedes-Benz E-Class compare with other midsize car configurations?
The E400 3.0L 6-cyl turbo RWD costs about $3,420 a year to fuel, $540 more than the class median of $2,880, and less than 3 of 10 midsize car configurations. The comparison covers all 195 rated midsize car configurations for MY2016, not weighted by sales.
Is the 2016 Mercedes-Benz E-Class different from the 2015 model?
The most efficient configuration moves from 25 to 23 MPG, down 2. Its annual cost goes from $3,160 to $3,420, $260 more. EPA lists 16 configurations for 2016 against 19 configurations for 2015. See the 2015 Mercedes-Benz E-Class for that year.