2003-2009 Mercedes-Benz E-Class MPG & Fuel Cost

EPA rates the 2003-2009 Mercedes-Benz E-Class at 14–27 MPG combined across 58 configurations and 7 model years. The most efficient version, the 2006 E320 Cdi 3.2L 6-cyl turbo RWD, is rated 27 MPG (23 city, 33 highway). By powertrain: Gas: 14–20 MPG; Diesel: 26–27 MPG.

The E320 Cdi 3.2L 6-cyl turbo RWD reached the generation's best combined rating, 27 MPG, in 2005 and 2006. The lowest top rating, 20 MPG, was in 2003 and 2004.

Yes. Ratings changed in 2004, 2005, 2006, 2007, 2008 and 2009.

The previous generation (2000-2002 Mercedes-Benz E-Class) is rated 17–21 MPG combined and costs $3,830–$4,730 a year to fuel; the 2003-2009 model is rated 14–27 MPG and costs $3,500–$5,740 a year.

Driving 15,000 miles a year at premium gasoline $5.36/gal (U.S. average, Sep 2026), the E350 3.5L 6-cyl RWD costs about $4,230 a year. Across all 8 configurations the cost runs $3,630–$5,360 a year. That is a $1,730 difference between the cheapest and the costliest configuration.

About $28.20 per 100 miles for the E350 3.5L 6-cyl RWD at premium gasoline $5.36/gal (U.S. average, Sep 2026), and between $24.20 and $35.73 across all configurations. That is the annual cost over 15,000 miles divided by 150.

The E350 3.5L 6-cyl RWD is rated 17 city and 24 highway MPG, so it is more efficient on the highway, by 7 MPG.

The E350 3.5L 6-cyl RWD costs about $4,230 a year to fuel, $960 more than the class median of $3,270, and less than 2 of 10 midsize car configurations. The comparison covers all 130 rated midsize car configurations for MY2009, not weighted by sales.

The most efficient configuration stays at 26 MPG. Its annual cost stays at $3,630. EPA lists 8 configurations for 2009 against 8 configurations for 2008. See the 2008 Mercedes-Benz E-Class for that year.