- Newest year: 2021
- Hybrid
- Small cars
2019-2021 Mercedes-Benz CLS-Class MPG & Fuel Cost
3 model years · 23–26 MPG combined
15,000 mi/yr · premium gasoline $5.36/gal (U.S. average, Sep 2026)
Cheaper to fuel than 5 of 10 small car configurations, MY2021. Ranked against all rated configurations, not sales-weighted.
2019-2021 Mercedes-Benz CLS-Class at a glance
The 2019-2021 Mercedes-Benz CLS-Class covers 3 model years in the EPA database (9 configurations in all), rated 23–26 MPG combined. The newest model year, 2021, costs about $3,140 a year to fuel for its most efficient version, the CLS450 3.0L 6-cyl turbo RWD (26 MPG), at premium gasoline $5.36/gal (U.S. average, Sep 2026). EPA changed the ratings in 2021; 2020 repeat the values of the year before.
2019-2021 Mercedes-Benz CLS-Class by model year
| Model year | Powertrains | Combined | $/yr | EPA ratings |
|---|---|---|---|---|
| 2021 | Hybrid | 23–26 MPG | $3,140–$3,510 | Ratings changed |
| 2020 | Hybrid | 23–26 MPG | $3,030–$3,430 | Same EPA ratings as 2019 |
| 2019 | Hybrid | 23–26 MPG | $3,030–$3,430 | First year |
What the 2021 CLS450 3.0L 6-cyl turbo RWD costs to drive
Per month
$262
$3,140 a year ÷ 12
Per 25 miles
$5.23
Per 100 miles
$20.93
Five years
$15,700
5 × the yearly cost, prices held at today's level
vs the small car median
$70less a year
Class median $3,210 a year, MY2021
Based on 15,000 miles a year and premium gasoline $5.36/gal (U.S. average, Sep 2026).
2021 Mercedes-Benz CLS-Class MPG
Versus 2020: The most efficient configuration stays at 26 MPG. Its annual cost goes from $3,030 to $3,140, $110 more.
Hybrid configurations (3)
| Trim | Engine | Drive | City | Hwy | Comb. | $/yr |
|---|---|---|---|---|---|---|
| CLS450 (Most efficient) | 3.0L 6-cyl turbo | RWD | 23 | 30 | 26 | $3,140 |
| CLS450 4matic | 3.0L 6-cyl turbo | 4WD | 22 | 29 | 25 | $3,220 |
| AMG CLS53 4matic Plus | 3.0L 6-cyl | 4WD | 21 | 26 | 23 | $3,510 |
3 configurations require or recommend higher-octane gasoline and are costed at premium gasoline $5.36/gal (U.S. average, Sep 2026).
2020 Mercedes-Benz CLS-Class MPG
Same EPA ratings as 2019
EPA lists the same ratings for the 2020 Mercedes-Benz CLS-Class as for the 2019 model, so the configurations and costs are the ones in the 2019 section above.See 2019
2019 Mercedes-Benz CLS-Class MPG
23–26 MPG · $3,030–$3,430/yr
Hybrid configurations (3)
| Trim | Engine | Drive | City | Hwy | Comb. | $/yr |
|---|---|---|---|---|---|---|
| CLS450 (Most efficient) | 3.0L 6-cyl turbo | RWD | 24 | 31 | 26 | $3,030 |
| CLS450 4matic | 3.0L 6-cyl turbo | 4WD | 23 | 30 | 26 | $3,120 |
| AMG CLS53 4matic Plus | 3.0L 6-cyl | 4WD | 21 | 27 | 23 | $3,430 |
3 configurations require or recommend higher-octane gasoline and are costed at premium gasoline $5.36/gal (U.S. average, Sep 2026).
Fuel cost by state
Yearly cost of the CLS450 3.0L 6-cyl turbo RWD: $3,740 in California and $2,720 in Texas, a $1,020 difference.
- California $3,740
- Washington $3,520
- New York $3,100
- Florida $2,860
- Texas $2,720
Similar cars
Closest combined MPG among MY2021 small car models.
Generations
Frequently asked questions
What gas mileage does the 2019-2021 Mercedes-Benz CLS-Class get?
EPA rates the 2019-2021 Mercedes-Benz CLS-Class at 23–26 MPG combined across 9 configurations and 3 model years. The most efficient version, the 2021 CLS450 3.0L 6-cyl turbo RWD, is rated 26 MPG (23 city, 30 highway).
Which years had the best MPG in the 2019-2021 Mercedes-Benz CLS-Class?
Every model year of the 2019-2021 Mercedes-Benz CLS-Class tops out at 26 MPG combined, so no year is better than another.
Did EPA ratings change during the 2019-2021 Mercedes-Benz CLS-Class?
Yes. Ratings changed in 2021. In 2020 the values repeat the year before.
How does the 2019-2021 Mercedes-Benz CLS-Class compare with the previous generation?
The previous generation (2015-2018 Mercedes-Benz CLS-Class) is rated 18–24 MPG combined and costs $3,400–$4,490 a year to fuel; the 2019-2021 model is rated 23–26 MPG and costs $3,030–$3,510 a year.
How much does it cost to fuel a 2021 Mercedes-Benz CLS-Class per year?
Driving 15,000 miles a year at premium gasoline $5.36/gal (U.S. average, Sep 2026), the CLS450 3.0L 6-cyl turbo RWD costs about $3,140 a year. Across all 3 configurations the cost runs $3,140–$3,510 a year. That is a $370 difference between the cheapest and the costliest configuration.
How much does it cost to drive a 2021 Mercedes-Benz CLS-Class 100 miles?
About $20.93 per 100 miles for the CLS450 3.0L 6-cyl turbo RWD at premium gasoline $5.36/gal (U.S. average, Sep 2026), and between $20.93 and $23.40 across all configurations. That is the annual cost over 15,000 miles divided by 150.
Is the 2021 Mercedes-Benz CLS-Class more efficient in the city or on the highway?
The CLS450 3.0L 6-cyl turbo RWD is rated 23 city and 30 highway MPG, so it is more efficient on the highway, by 7 MPG.
How does the 2021 Mercedes-Benz CLS-Class compare with other small car configurations?
The CLS450 3.0L 6-cyl turbo RWD costs about $3,140 a year to fuel, $70 less than the class median of $3,210, and less than 5 of 10 small car configurations. The comparison covers all 298 rated small car configurations for MY2021, not weighted by sales.
Is the 2021 Mercedes-Benz CLS-Class different from the 2020 model?
The most efficient configuration stays at 26 MPG. Its annual cost goes from $3,030 to $3,140, $110 more. EPA lists 3 configurations for 2021 against 3 configurations for 2020. See the 2020 Mercedes-Benz CLS-Class for that year.