- Newest year: 2006
- Gas
- Small cars
2006 Mercedes-Benz CLS-Class MPG & Fuel Cost
2 configurations · 15–16 MPG combined
15,000 mi/yr · premium gasoline $5.36/gal (U.S. average, Sep 2026)
Cheaper to fuel than 1 of 10 small car configurations, MY2006. Ranked against all rated configurations, not sales-weighted.
2006 Mercedes-Benz CLS-Class at a glance
The 2006 Mercedes-Benz CLS-Class has 2 configurations in the EPA database, rated 15–16 MPG combined. The most efficient is the CLS500 5.0L 8-cyl RWD at 16 MPG, which costs about $5,020 a year to fuel at premium gasoline $5.36/gal (U.S. average, Sep 2026). Annual fuel cost across the configurations runs from $5,020 to $5,360, a $340 difference. The CLS500 5.0L 8-cyl RWD costs less to fuel than 1 of 10 small car configurations rated for MY2006 (class median $3,650 a year).
EPA re-estimated ratings of 1985-2007 vehicles under its 2008 method; these figures are the re-estimated values.
What the 2006 CLS500 5.0L 8-cyl RWD costs to drive
Per month
$418
$5,020 a year ÷ 12
Per 25 miles
$8.37
Per 100 miles
$33.47
Five years
$25,100
5 × the yearly cost, prices held at today's level
vs the small car median
$1,370more a year
Class median $3,650 a year, MY2006
Based on 15,000 miles a year and premium gasoline $5.36/gal (U.S. average, Sep 2026).
2006 Mercedes-Benz CLS-Class MPG
EPA re-estimated ratings of 1985-2007 vehicles under its 2008 method; these figures are the re-estimated values.
Gas configurations (2)
| Trim | Engine | Drive | City | Hwy | Comb. | $/yr |
|---|---|---|---|---|---|---|
| CLS500 (Most efficient) | 5.0L 8-cyl | RWD | 14 | 20 | 16 | $5,020 |
| CLS55 AMG | 5.4L 8-cyl supercharged | RWD | 13 | 19 | 15 | $5,360 |
2 configurations require or recommend higher-octane gasoline and are costed at premium gasoline $5.36/gal (U.S. average, Sep 2026).
Fuel cost by state
Yearly cost of the CLS500 5.0L 8-cyl RWD: $5,990 in California and $4,350 in Texas, a $1,640 difference.
- California $5,990
- Washington $5,630
- New York $4,960
- Florida $4,590
- Texas $4,350
Similar cars
Closest combined MPG among MY2006 small car models.
Generations
Frequently asked questions
What gas mileage does the 2006 Mercedes-Benz CLS-Class get?
EPA rates the 2006 Mercedes-Benz CLS-Class at 15–16 MPG combined across 2 configurations. The most efficient, the CLS500 5.0L 8-cyl RWD, is rated 16 MPG combined (14 city / 20 highway).
How much does it cost to fuel a 2006 Mercedes-Benz CLS-Class per year?
Driving 15,000 miles a year at premium gasoline $5.36/gal (U.S. average, Sep 2026), the CLS500 5.0L 8-cyl RWD costs about $5,020 a year. Across all 2 configurations the cost runs $5,020–$5,360 a year. That is a $340 difference between the cheapest and the costliest configuration.
How much does it cost to drive a 2006 Mercedes-Benz CLS-Class 100 miles?
About $33.47 per 100 miles for the CLS500 5.0L 8-cyl RWD at premium gasoline $5.36/gal (U.S. average, Sep 2026), and between $33.47 and $35.73 across all configurations. That is the annual cost over 15,000 miles divided by 150.
Is the 2006 Mercedes-Benz CLS-Class more efficient in the city or on the highway?
The CLS500 5.0L 8-cyl RWD is rated 14 city and 20 highway MPG, so it is more efficient on the highway, by 6 MPG.
How does the 2006 Mercedes-Benz CLS-Class compare with other small car configurations?
The CLS500 5.0L 8-cyl RWD costs about $5,020 a year to fuel, $1,370 more than the class median of $3,650, and less than 1 of 10 small car configurations. The comparison covers all 286 rated small car configurations for MY2006, not weighted by sales.