- Newest year: 2022
- Hybrid
- Small cars
2022 Mercedes-Benz CLS-Class MPG & Fuel Cost
1 configuration · 25 MPG combined
15,000 mi/yr · premium gasoline $5.36/gal (U.S. average, Sep 2026)
Cheaper to fuel than 5 of 10 small car configurations, MY2022. Ranked against all rated configurations, not sales-weighted.
2022 Mercedes-Benz CLS-Class at a glance
The 2022 Mercedes-Benz CLS-Class has 1 configuration in the EPA database, rated 25 MPG combined. The most efficient is the CLS450 4matic 3.0L 6-cyl turbo 4WD at 25 MPG, which costs about $3,240 a year to fuel at premium gasoline $5.36/gal (U.S. average, Sep 2026). The CLS450 4matic 3.0L 6-cyl turbo 4WD costs less to fuel than 5 of 10 small car configurations rated for MY2022 (class median $3,240 a year).
What the 2022 CLS450 4matic 3.0L 6-cyl turbo 4WD costs to drive
Per month
$270
$3,240 a year ÷ 12
Per 25 miles
$5.40
Per 100 miles
$21.60
Five years
$16,200
5 × the yearly cost, prices held at today's level
vs the small car median
Same
Class median $3,240 a year, MY2022
Based on 15,000 miles a year and premium gasoline $5.36/gal (U.S. average, Sep 2026).
2022 Mercedes-Benz CLS-Class MPG
Hybrid configurations (1)
| Trim | Engine | Drive | City | Hwy | Comb. | $/yr |
|---|---|---|---|---|---|---|
| CLS450 4matic (Most efficient) | 3.0L 6-cyl turbo | 4WD | 22 | 30 | 25 | $3,240 |
1 configuration requires or recommends higher-octane gasoline and is costed at premium gasoline $5.36/gal (U.S. average, Sep 2026).
Fuel cost by state
Yearly cost of the CLS450 4matic 3.0L 6-cyl turbo 4WD: $3,860 in California and $2,810 in Texas, a $1,050 difference.
- California $3,860
- Washington $3,630
- New York $3,200
- Florida $2,950
- Texas $2,810
Similar cars
Closest combined MPG among MY2022 small car models.
Generations
Frequently asked questions
How does the 2022 Mercedes-Benz CLS-Class compare with the previous generation?
The previous generation (2019-2021 Mercedes-Benz CLS-Class) is rated 23–26 MPG combined and costs $3,030–$3,510 a year to fuel; the 2022 model is rated 25 MPG and costs $3,240 a year.
What gas mileage does the 2022 Mercedes-Benz CLS-Class get?
EPA rates the 2022 Mercedes-Benz CLS-Class at 25 MPG combined across 1 configuration. The most efficient, the CLS450 4matic 3.0L 6-cyl turbo 4WD, is rated 25 MPG combined (22 city / 30 highway).
How much does it cost to fuel a 2022 Mercedes-Benz CLS-Class per year?
Driving 15,000 miles a year at premium gasoline $5.36/gal (U.S. average, Sep 2026), the CLS450 4matic 3.0L 6-cyl turbo 4WD costs about $3,240 a year. Across all 1 configuration the cost runs $3,240 a year.
How much does it cost to drive a 2022 Mercedes-Benz CLS-Class 100 miles?
About $21.60 per 100 miles for the CLS450 4matic 3.0L 6-cyl turbo 4WD at premium gasoline $5.36/gal (U.S. average, Sep 2026). That is the annual cost over 15,000 miles divided by 150.
Is the 2022 Mercedes-Benz CLS-Class more efficient in the city or on the highway?
The CLS450 4matic 3.0L 6-cyl turbo 4WD is rated 22 city and 30 highway MPG, so it is more efficient on the highway, by 8 MPG.
How does the 2022 Mercedes-Benz CLS-Class compare with other small car configurations?
The CLS450 4matic 3.0L 6-cyl turbo 4WD costs about $3,240 a year to fuel, the same as the class median of $3,240, and less than 5 of 10 small car configurations. The comparison covers all 287 rated small car configurations for MY2022, not weighted by sales.
Is the 2022 Mercedes-Benz CLS-Class different from the 2021 model?
The most efficient configuration moves from 26 to 25 MPG, down 1. Its annual cost goes from $3,140 to $3,240, $100 more. EPA lists 1 configuration for 2022 against 3 configurations for 2021. See the 2021 Mercedes-Benz CLS-Class for that year.