2006-2013 Lexus IS MPG & Fuel Cost

EPA rates the 2006-2013 Lexus IS at 20–24 MPG combined across 34 configurations and 8 model years. The most efficient version, the 2013 250/IS 250C 2.5L 6-cyl RWD, is rated 24 MPG (21 city, 29 highway).

Every model year of the 2006-2013 Lexus IS tops out at 24 MPG combined, so no year is better than another.

Yes. Ratings changed in 2007, 2008, 2010, 2011, 2012 and 2013. In 2009 the values repeat the year before.

The previous generation (2001-2005 Lexus IS) is rated 18–19 MPG combined and costs $4,230–$4,460 a year to fuel; the 2006-2013 model is rated 20–24 MPG and costs $3,300–$4,020 a year.

Driving 15,000 miles a year at premium gasoline $5.36/gal (U.S. average, Sep 2026), the 250/IS 250C 2.5L 6-cyl RWD costs about $3,360 a year. Across all 4 configurations the cost runs $3,360–$3,730 a year. That is a $370 difference between the cheapest and the costliest configuration.

About $22.40 per 100 miles for the 250/IS 250C 2.5L 6-cyl RWD at premium gasoline $5.36/gal (U.S. average, Sep 2026), and between $22.40 and $24.87 across all configurations. That is the annual cost over 15,000 miles divided by 150.

The 250/IS 250C 2.5L 6-cyl RWD is rated 21 city and 29 highway MPG, so it is more efficient on the highway, by 8 MPG.

The 250/IS 250C 2.5L 6-cyl RWD costs about $3,360 a year to fuel, $170 more than the class median of $3,190, and less than 5 of 10 small car configurations. The comparison covers all 386 rated small car configurations for MY2013, not weighted by sales.

The most efficient configuration stays at 24 MPG. Its annual cost goes from $3,300 to $3,360, $60 more. EPA lists 4 configurations for 2013 against 5 configurations for 2012. See the 2012 Lexus IS for that year.