- Newest year: 2006
- Gas
- Standard pickups
2006 Isuzu i-350 Crew Cab MPG & Fuel Cost
1 configuration · 17 MPG combined
15,000 mi/yr · regular gasoline $4.36/gal (U.S. average, Sep 2026)
Cheaper to fuel than 6 of 10 standard pickup configurations, MY2006. Ranked against all rated configurations, not sales-weighted.
2006 Isuzu i-350 Crew Cab at a glance
The 2006 Isuzu i-350 Crew Cab has 1 configuration in the EPA database, rated 17 MPG combined. The most efficient is the i-350 Crew Cab 3.5L 5-cyl 4WD at 17 MPG, which costs about $3,840 a year to fuel at regular gasoline $4.36/gal (U.S. average, Sep 2026). The i-350 Crew Cab 3.5L 5-cyl 4WD costs less to fuel than 6 of 10 standard pickup configurations rated for MY2006 (class median $4,080 a year).
EPA re-estimated ratings of 1985-2007 vehicles under its 2008 method; these figures are the re-estimated values.
What the 2006 i-350 Crew Cab 3.5L 5-cyl 4WD costs to drive
Per month
$320
$3,840 a year ÷ 12
Per 25 miles
$6.40
Per 100 miles
$25.60
Five years
$19,200
5 × the yearly cost, prices held at today's level
vs the standard pickup median
$240less a year
Class median $4,080 a year, MY2006
Based on 15,000 miles a year and regular gasoline $4.36/gal (U.S. average, Sep 2026).
2006 Isuzu i-350 Crew Cab MPG
EPA re-estimated ratings of 1985-2007 vehicles under its 2008 method; these figures are the re-estimated values.
Gas configurations (1)
| Trim | Engine | Drive | City | Hwy | Comb. | $/yr |
|---|---|---|---|---|---|---|
| i-350 Crew Cab (Most efficient) | 3.5L 5-cyl | 4WD | 16 | 21 | 17 | $3,840 |
Fuel cost by state
Yearly cost of the i-350 Crew Cab 3.5L 5-cyl 4WD: $5,230 in California and $3,350 in Texas, a $1,880 difference.
- California $5,230
- Washington $4,840
- New York $3,840
- Florida $3,630
- Texas $3,350
Similar cars
Closest combined MPG among MY2006 standard pickup models.
Generations
- 2006
Frequently asked questions
What gas mileage does the 2006 Isuzu i-350 Crew Cab get?
EPA rates the 2006 Isuzu i-350 Crew Cab at 17 MPG combined across 1 configuration. The most efficient, the i-350 Crew Cab 3.5L 5-cyl 4WD, is rated 17 MPG combined (16 city / 21 highway).
How much does it cost to fuel a 2006 Isuzu i-350 Crew Cab per year?
Driving 15,000 miles a year at regular gasoline $4.36/gal (U.S. average, Sep 2026), the i-350 Crew Cab 3.5L 5-cyl 4WD costs about $3,840 a year. Across all 1 configuration the cost runs $3,840 a year.
How much does it cost to drive a 2006 Isuzu i-350 Crew Cab 100 miles?
About $25.60 per 100 miles for the i-350 Crew Cab 3.5L 5-cyl 4WD at regular gasoline $4.36/gal (U.S. average, Sep 2026). That is the annual cost over 15,000 miles divided by 150.
Is the 2006 Isuzu i-350 Crew Cab more efficient in the city or on the highway?
The i-350 Crew Cab 3.5L 5-cyl 4WD is rated 16 city and 21 highway MPG, so it is more efficient on the highway, by 5 MPG.
How does the 2006 Isuzu i-350 Crew Cab compare with other standard pickup configurations?
The i-350 Crew Cab 3.5L 5-cyl 4WD costs about $3,840 a year to fuel, $240 less than the class median of $4,080, and less than 6 of 10 standard pickup configurations. The comparison covers all 155 rated standard pickup configurations for MY2006, not weighted by sales.