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  • MY2006–2006

Isuzu i-350 Crew Cab MPG & Fuel Cost by Year

1 model years · 2006–2006

17 MPG
Combined
16 MPG
City
21 MPG
Highway
Annual cost · MY2006 i-350 Crew Cab 3.5L 5-cyl 4WD
$3,840

15,000 mi/yr · regular gasoline $4.36/gal (U.S. average, Sep 2026)

All Isuzu models

Isuzu i-350 Crew Cab fuel economy at a glance

EPA has rated the Isuzu i-350 Crew Cab for 1 model years, 2006 to 2006. Across those years its combined rating runs 17 MPG. The latest model year, 2006, has 1 configuration rated 17 MPG combined and costing $3,840 a year to fuel at regular gasoline $4.36/gal (U.S. average, Sep 2026). The most efficient configuration on record since 2006 is the 2006 i-350 Crew Cab 3.5L 5-cyl 4WD, at 17 MPG.

Isuzu i-350 Crew Cab MPG by year

Isuzu i-350 Crew Cab: combined fuel economy and annual fuel cost for each model year, grouped by generation
Year Gas (MPG) $/yr
2006 Generation page
2006 17 $3,840

Costs use the current EIA price set and 15,000 miles a year for every year, so years are comparable. Green marks the best year for each powertrain.

Isuzu i-350 Crew Cab generations

1 generations between 2006 and 2006. Open one for the table of every model year and configuration.

2006 powertrain options

Gas · 3.5L
Combined
17 MPG
Per year
$3,840
See gas configurations
EPA ratings: fueleconomy.gov file of Sep 29, 2026 · regular gasoline $4.36/gal (U.S. average, Sep 2026) · 15,000 mi/yr, 55% city / 45% highway · How we calculate

Frequently asked questions

What is the Isuzu i-350 Crew Cab's gas mileage by year?

EPA combined ratings for the Isuzu i-350 Crew Cab run 17 MPG across model years 2006 to 2006. The latest year, 2006, is rated 17 MPG.

Which Isuzu i-350 Crew Cab model year has the best gas mileage?

The 2006 Isuzu i-350 Crew Cab i-350 Crew Cab 3.5L 5-cyl 4WD has the highest combined rating since 2006, at 17 MPG.

How much does a Isuzu i-350 Crew Cab cost to fuel per year?

For MY2006, EPA-rated configurations cost $3,840 a year to fuel, driving 15,000 miles at regular gasoline $4.36/gal (U.S. average, Sep 2026). The most efficient one costs $3,840.