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2005-2006 Infiniti Q45 (F50)
Shown: 2005-2006 Infiniti Q45 (F50). Photo: IFCAR, Public domain, via Wikimedia Commons
  • Newest year: 2006
  • Gas
  • Midsize cars

2002-2006 Infiniti Q45 MPG & Fuel Cost

5 model years · 18 MPG combined

18 MPG
Combined
16 MPG
City
22 MPG
Highway
Annual fuel cost · Q45 4.5L 8-cyl RWD
$4,460

15,000 mi/yr · premium gasoline $5.36/gal (U.S. average, Sep 2026)

Cheaper to fuel than 1 of 10 midsize car configurations, MY2006. Ranked against all rated configurations, not sales-weighted.

2002-2006 Infiniti Q45 at a glance

The 2002-2006 Infiniti Q45 covers 5 model years in the EPA database (6 configurations in all), rated 18 MPG combined. The newest model year, 2006, costs about $4,460 a year to fuel for its most efficient version, the Q45 4.5L 8-cyl RWD (18 MPG), at premium gasoline $5.36/gal (U.S. average, Sep 2026). EPA changed the ratings in 2003, 2004 and 2006; 2005 repeat the values of the year before.

EPA re-estimated ratings of 1985-2007 vehicles under its 2008 method; these figures are the re-estimated values.

2002-2006 Infiniti Q45 by model year

2002-2006 Infiniti Q45: EPA combined rating and yearly fuel cost for each model year
Model yearPowertrainsCombined$/yrEPA ratings
2006 Gas 18 MPG $4,460 Ratings changed
2005 Gas 18 MPG $4,460 Same EPA ratings as 2004
2004 Gas 18 MPG $4,460 Ratings changed
2003 Gas 18 MPG $4,460 Ratings changed
2002 Gas 18 MPG $4,460 First year

What the 2006 Q45 4.5L 8-cyl RWD costs to drive

Per month

$372

$4,460 a year ÷ 12

Per 25 miles

$7.43

Per 100 miles

$29.73

Five years

$22,300

5 × the yearly cost, prices held at today's level

vs the midsize car median

$830more a year

Class median $3,630 a year, MY2006

Based on 15,000 miles a year and premium gasoline $5.36/gal (U.S. average, Sep 2026).

2006 Infiniti Q45 MPG

EPA re-estimated ratings of 1985-2007 vehicles under its 2008 method; these figures are the re-estimated values.

Versus 2005: The most efficient configuration stays at 18 MPG. Its annual cost stays at $4,460.

Gas · 4.5L
Combined
18 MPG
Per year
$4,460

Gas configurations (2)

2006 Infiniti Q45 gas configurations: EPA ratings and annual cost
TrimEngineDriveCityHwyComb.$/yr
Q45 (Most efficient) 4.5L 8-cyl RWD 16 22 18 $4,460
Sport 4.5L 8-cyl RWD 15 22 18 $4,460

2 configurations require or recommend higher-octane gasoline and are costed at premium gasoline $5.36/gal (U.S. average, Sep 2026).

2005 Infiniti Q45 MPG

Same EPA ratings as 2004

EPA re-estimated ratings of 1985-2007 vehicles under its 2008 method; these figures are the re-estimated values.

EPA lists the same ratings for the 2005 Infiniti Q45 as for the 2004 model, so the configurations and costs are the ones in the 2004 section above.See 2004

2004 Infiniti Q45 MPG

18 MPG · $4,460/yr

EPA re-estimated ratings of 1985-2007 vehicles under its 2008 method; these figures are the re-estimated values.

Versus 2003: The most efficient configuration stays at 18 MPG. Its annual cost stays at $4,460.

Gas · 4.5L
Combined
18 MPG
Per year
$4,460

Gas configurations (1)

2004 Infiniti Q45 gas configurations: EPA ratings and annual cost
TrimEngineDriveCityHwyComb.$/yr
Q45 (Most efficient) 4.5L 8-cyl RWD 16 22 18 $4,460

1 configuration requires or recommends higher-octane gasoline and is costed at premium gasoline $5.36/gal (U.S. average, Sep 2026).

2003 Infiniti Q45 MPG

18 MPG · $4,460/yr

EPA re-estimated ratings of 1985-2007 vehicles under its 2008 method; these figures are the re-estimated values.

Versus 2002: The most efficient configuration stays at 18 MPG. Its annual cost stays at $4,460.

Gas · 4.5L
Combined
18 MPG
Per year
$4,460

Gas configurations (1)

2003 Infiniti Q45 gas configurations: EPA ratings and annual cost
TrimEngineDriveCityHwyComb.$/yr
Q45 (Most efficient) 4.5L 8-cyl RWD 16 22 18 $4,460

1 configuration requires or recommends higher-octane gasoline and is costed at premium gasoline $5.36/gal (U.S. average, Sep 2026).

2002 Infiniti Q45 MPG

18 MPG · $4,460/yr

EPA re-estimated ratings of 1985-2007 vehicles under its 2008 method; these figures are the re-estimated values.

Gas · 4.5L
Combined
18 MPG
Per year
$4,460

Gas configurations (1)

2002 Infiniti Q45 gas configurations: EPA ratings and annual cost
TrimEngineDriveCityHwyComb.$/yr
Q45 (Most efficient) 4.5L 8-cyl RWD 16 23 18 $4,460

1 configuration requires or recommends higher-octane gasoline and is costed at premium gasoline $5.36/gal (U.S. average, Sep 2026).

Fuel cost by state

Yearly cost of the Q45 4.5L 8-cyl RWD: $5,320 in California and $3,870 in Texas, a $1,450 difference.

Gasoline prices: California: California state average; Washington: Washington state average; New York: New York state average; Florida: Florida state average; Texas: Texas state average (Sep 2026).
Fuel cost in every state

Similar cars

Closest combined MPG among MY2006 midsize car models.

EPA ratings: fueleconomy.gov file of Sep 29, 2026 · Prices: EIA regular gasoline, U.S. average, Sep 2026 ($4.36/gal) · 15,000 mi/yr, 55% city / 45% highway · How we calculate

Generations

Frequently asked questions

What gas mileage does the 2002-2006 Infiniti Q45 get?

EPA rates the 2002-2006 Infiniti Q45 at 18 MPG combined across 6 configurations and 5 model years. The most efficient version, the 2006 Q45 4.5L 8-cyl RWD, is rated 18 MPG (16 city, 22 highway).

Which years had the best MPG in the 2002-2006 Infiniti Q45?

Every model year of the 2002-2006 Infiniti Q45 tops out at 18 MPG combined, so no year is better than another.

Did EPA ratings change during the 2002-2006 Infiniti Q45?

Yes. Ratings changed in 2003, 2004 and 2006. In 2005 the values repeat the year before.

How does the 2002-2006 Infiniti Q45 compare with the previous generation?

The previous generation (2000-2001 Infiniti Q45) is rated 18 MPG combined and costs $4,460 a year to fuel; the 2002-2006 model is rated 18 MPG and costs $4,460 a year.

How much does it cost to fuel a 2006 Infiniti Q45 per year?

Driving 15,000 miles a year at premium gasoline $5.36/gal (U.S. average, Sep 2026), the Q45 4.5L 8-cyl RWD costs about $4,460 a year. Across all 2 configurations the cost runs $4,460 a year.

How much does it cost to drive a 2006 Infiniti Q45 100 miles?

About $29.73 per 100 miles for the Q45 4.5L 8-cyl RWD at premium gasoline $5.36/gal (U.S. average, Sep 2026). That is the annual cost over 15,000 miles divided by 150.

Is the 2006 Infiniti Q45 more efficient in the city or on the highway?

The Q45 4.5L 8-cyl RWD is rated 16 city and 22 highway MPG, so it is more efficient on the highway, by 6 MPG.

How does the 2006 Infiniti Q45 compare with other midsize car configurations?

The Q45 4.5L 8-cyl RWD costs about $4,460 a year to fuel, $830 more than the class median of $3,630, and less than 1 of 10 midsize car configurations. The comparison covers all 133 rated midsize car configurations for MY2006, not weighted by sales.

Is the 2006 Infiniti Q45 different from the 2005 model?

The most efficient configuration stays at 18 MPG. Its annual cost stays at $4,460. EPA lists 2 configurations for 2006 against 1 configuration for 2005. See the 2005 Infiniti Q45 for that year.