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2005-2006 Infiniti Q45 (F50)
Shown: 2005-2006 Infiniti Q45 (F50). Photo: IFCAR, Public domain, via Wikimedia Commons
  • Gas
  • Midsize cars
  • MY2000–2006

Infiniti Q45 MPG & Fuel Cost by Year

7 model years · 2000–2006

18 MPG
Combined
16 MPG
City
22 MPG
Highway
Annual cost · MY2006 Q45 4.5L 8-cyl RWD
$4,460

15,000 mi/yr · premium gasoline $5.36/gal (U.S. average, Sep 2026)

All Infiniti models

Infiniti Q45 fuel economy at a glance

EPA has rated the Infiniti Q45 for 7 model years, 2000 to 2006. Across those years its combined rating runs 18 MPG. The latest model year, 2006, has 2 configurations rated 18 MPG combined and costing $4,460 a year to fuel at premium gasoline $5.36/gal (U.S. average, Sep 2026). The most efficient configuration on record since 2000 is the 2006 Q45 4.5L 8-cyl RWD, at 18 MPG. EPA ratings go back to 1984: the earliest rating on this page is 17 MPG in 1990.

Infiniti Q45 MPG by year

1820 200020022006 Gas 1820 200020022006 Gas
Combined MPG: the line is the most efficient configuration, the shaded band reaches down to the least efficient. Dotted lines mark new generations.
Infiniti Q45: combined fuel economy and annual fuel cost for each model year, grouped by generation
Year Gas (MPG) $/yr
2002-2006 (F50) Generation page
2006 18 $4,460
2005 18 $4,460
2004 18 $4,460
2003 18 $4,460
2002 18 $4,460
2000-2001 (Y33) Generation page
2001 18 $4,460
2000 18 $4,460

Costs use the current EIA price set and 15,000 miles a year for every year, so years are comparable. Green marks the best year for each powertrain.

Infiniti Q45 generations

2 generations between 2000 and 2006. Open one for the table of every model year and configuration.

2006 powertrain options

Gas · 4.5L
Combined
18 MPG
Per year
$4,460
See gas configurations

Infiniti Q45 MPG history, 1990–1999

Infiniti Q45: combined MPG range by model year, 1990–1999
YearGas (MPG)
1999 18
1998 18
1997 18
1996 17
1995 16–17
1994 16–17
1993 15–17
1992 15–17
Show 2 more years
Infiniti Q45: combined MPG range by model year, 1990–1999 (+2)
YearGas (MPG)
199115–17
199017

EPA re-estimated the ratings of pre-2008 vehicles under its 2008 method; these are the re-estimated values.

EPA ratings: fueleconomy.gov file of Sep 29, 2026 · premium gasoline $5.36/gal (U.S. average, Sep 2026) · 15,000 mi/yr, 55% city / 45% highway · How we calculate

Frequently asked questions

What is the Infiniti Q45's gas mileage by year?

EPA combined ratings for the Infiniti Q45 run 18 MPG across model years 2000 to 2006. The latest year, 2006, is rated 18 MPG.

Which Infiniti Q45 model year has the best gas mileage?

The 2006 Infiniti Q45 Q45 4.5L 8-cyl RWD has the highest combined rating since 2000, at 18 MPG.

How much does a Infiniti Q45 cost to fuel per year?

For MY2006, EPA-rated configurations cost $4,460 a year to fuel, driving 15,000 miles at premium gasoline $5.36/gal (U.S. average, Sep 2026). The most efficient one costs $4,460.

Has the Infiniti Q45's fuel economy improved over time?

Not much. The most efficient configuration is rated 18 MPG in both 2000 and 2006. Going back further, the best rating in 1984 was 17 MPG.

Which Infiniti Q45 model years have the same ratings?

EPA lists identical ratings as the previous year for 2001, 2005. The generation pages mark those years "same EPA ratings" and point to the year that holds the full table.

How many generations of the Infiniti Q45 are there?

EPA data covers 2 generations of the Infiniti Q45: 2002-2006, 2000-2001. Each has its own page with a table for every model year.