- Newest year: 2006
- Gas
- Standard pickups
2006 Isuzu i-280 Extended Cab MPG & Fuel Cost
2 configurations · 17–21 MPG combined
15,000 mi/yr · regular gasoline $4.36/gal (U.S. average, Sep 2026)
Cheaper to fuel than 9 of 10 standard pickup configurations, MY2006. Ranked against all rated configurations, not sales-weighted.
2006 Isuzu i-280 Extended Cab at a glance
The 2006 Isuzu i-280 Extended Cab has 2 configurations in the EPA database, rated 17–21 MPG combined. The most efficient is the i-280 Extended Cab 2.8L 4-cyl RWD at 21 MPG, which costs about $3,110 a year to fuel at regular gasoline $4.36/gal (U.S. average, Sep 2026). Annual fuel cost across the configurations runs from $3,110 to $3,840, a $730 difference. The i-280 Extended Cab 2.8L 4-cyl RWD costs less to fuel than 9 of 10 standard pickup configurations rated for MY2006 (class median $4,080 a year).
EPA re-estimated ratings of 1985-2007 vehicles under its 2008 method; these figures are the re-estimated values.
What the 2006 i-280 Extended Cab 2.8L 4-cyl RWD costs to drive
Per month
$259
$3,110 a year ÷ 12
Per 25 miles
$5.18
Per 100 miles
$20.73
Five years
$15,550
5 × the yearly cost, prices held at today's level
vs the standard pickup median
$970less a year
Class median $4,080 a year, MY2006
Based on 15,000 miles a year and regular gasoline $4.36/gal (U.S. average, Sep 2026).
2006 Isuzu i-280 Extended Cab MPG
EPA re-estimated ratings of 1985-2007 vehicles under its 2008 method; these figures are the re-estimated values.
Gas configurations (2)
| Trim | Engine | Drive | City | Hwy | Comb. | $/yr |
|---|---|---|---|---|---|---|
| i-280 Extended Cab 2.8L 4-cyl RWD Manual 5-spd (Most efficient) | 2.8L 4-cyl | RWD | 18 | 25 | 21 | $3,110 |
| i-280 Extended Cab 2.8L 4-cyl RWD Automatic 4-spd | 2.8L 4-cyl | RWD | 15 | 22 | 17 | $3,840 |
Fuel cost by state
Yearly cost of the i-280 Extended Cab 2.8L 4-cyl RWD: $4,230 in California and $2,710 in Texas, a $1,520 difference.
- California $4,230
- Washington $3,920
- New York $3,110
- Florida $2,940
- Texas $2,710
Similar cars
Closest combined MPG among MY2006 standard pickup models.
Generations
- 2006
Frequently asked questions
What gas mileage does the 2006 Isuzu i-280 Extended Cab get?
EPA rates the 2006 Isuzu i-280 Extended Cab at 17–21 MPG combined across 2 configurations. The most efficient, the i-280 Extended Cab 2.8L 4-cyl RWD, is rated 21 MPG combined (18 city / 25 highway).
How much does it cost to fuel a 2006 Isuzu i-280 Extended Cab per year?
Driving 15,000 miles a year at regular gasoline $4.36/gal (U.S. average, Sep 2026), the i-280 Extended Cab 2.8L 4-cyl RWD costs about $3,110 a year. Across all 2 configurations the cost runs $3,110–$3,840 a year. That is a $730 difference between the cheapest and the costliest configuration.
How much does it cost to drive a 2006 Isuzu i-280 Extended Cab 100 miles?
About $20.73 per 100 miles for the i-280 Extended Cab 2.8L 4-cyl RWD at regular gasoline $4.36/gal (U.S. average, Sep 2026), and between $20.73 and $25.60 across all configurations. That is the annual cost over 15,000 miles divided by 150.
Is the 2006 Isuzu i-280 Extended Cab more efficient in the city or on the highway?
The i-280 Extended Cab 2.8L 4-cyl RWD is rated 18 city and 25 highway MPG, so it is more efficient on the highway, by 7 MPG.
How does the 2006 Isuzu i-280 Extended Cab compare with other standard pickup configurations?
The i-280 Extended Cab 2.8L 4-cyl RWD costs about $3,110 a year to fuel, $970 less than the class median of $4,080, and less than 9 of 10 standard pickup configurations. The comparison covers all 155 rated standard pickup configurations for MY2006, not weighted by sales.