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2006 Infiniti M35x
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  • MY2003–2010

Infiniti M45 MPG & Fuel Cost by Year

7 model years · 2003–2010

18 MPG
Combined
16 MPG
City
21 MPG
Highway
Annual cost · MY2010 M45 4.5L 8-cyl RWD
$4,460

15,000 mi/yr · premium gasoline $5.36/gal (U.S. average, Sep 2026)

All Infiniti models

Infiniti M45 fuel economy at a glance

EPA has rated the Infiniti M45 for 7 model years, 2003 to 2010. Across those years its combined rating runs 16–18 MPG. The latest model year, 2010, has 2 configurations rated 16–18 MPG combined and costing $4,460–$5,020 a year to fuel at premium gasoline $5.36/gal (U.S. average, Sep 2026). The most efficient configuration on record since 2003 is the 2010 M45 4.5L 8-cyl RWD, at 18 MPG.

Infiniti M45 MPG by year

1618 200320062010 Gas 1618 200320062010 Gas
Combined MPG: the line is the most efficient configuration, the shaded band reaches down to the least efficient. Dotted lines mark new generations.
Infiniti M45: combined fuel economy and annual fuel cost for each model year, grouped by generation
Year Gas (MPG) $/yr
2006-2010 (3rd gen) Generation page
2010 16–18 $4,460–$5,020
2009 16–18 $4,460–$5,020
2008 16–18 $4,460–$5,020
2007 18 $4,460
2006 18 $4,460
2003-2004 (2nd gen) Generation page
2004 18 $4,460
2003 18 $4,460

Costs use the current EIA price set and 15,000 miles a year for every year, so years are comparable. Green marks the best year for each powertrain.

Infiniti M45 generations

2 generations between 2003 and 2010. Open one for the table of every model year and configuration.

2010 powertrain options

Gas · 4.5L
Combined
16–18 MPG
Per year
$4,460–$5,020
See gas configurations
EPA ratings: fueleconomy.gov file of Sep 29, 2026 · premium gasoline $5.36/gal (U.S. average, Sep 2026) · 15,000 mi/yr, 55% city / 45% highway · How we calculate

Frequently asked questions

What is the Infiniti M45's gas mileage by year?

EPA combined ratings for the Infiniti M45 run 16–18 MPG across model years 2003 to 2010. The latest year, 2010, is rated 16–18 MPG.

Which Infiniti M45 model year has the best gas mileage?

The 2010 Infiniti M45 M45 4.5L 8-cyl RWD has the highest combined rating since 2003, at 18 MPG.

How much does a Infiniti M45 cost to fuel per year?

For MY2010, EPA-rated configurations cost $4,460–$5,020 a year to fuel, driving 15,000 miles at premium gasoline $5.36/gal (U.S. average, Sep 2026). The most efficient one costs $4,460.

Has the Infiniti M45's fuel economy improved over time?

Not much. The most efficient configuration is rated 18 MPG in both 2003 and 2010.

Which Infiniti M45 model years have the same ratings?

EPA lists identical ratings as the previous year for 2004, 2007, 2009. The generation pages mark those years "same EPA ratings" and point to the year that holds the full table.

How many generations of the Infiniti M45 are there?

EPA data covers 2 generations of the Infiniti M45: 2006-2010, 2003-2004. Each has its own page with a table for every model year.